Molecular Basis for the Selective Inhibition of Respiratory Syncytial Virus RNA Polymerase by 2'-Fluoro-4'-Chloromethyl-Cytidine Triphosphate

Respiratory syncytial virus (RSV) causes severe lower respiratory tract infections, yet no vaccines or effective therapeutics are available. ALS-8176 is a first-in-class nucleoside analog prodrug effective in RSV-infected adult volunteers, and currently under evaluation in hospitalized infants. Here...

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Detalles Bibliográficos
Autores principales: Deval, Jerome, Hong, Jin, Wang, Guangyi, Taylor, Josh, Smith, Lucas K., Fung, Amy, Stevens, Sarah K., Liu, Hong, Jin, Zhinan, Dyatkina, Natalia, Prhavc, Marija, Stoycheva, Antitsa D., Serebryany, Vladimir, Liu, Jyanwei, Smith, David B., Tam, Yuen, Zhang, Qingling, Moore, Martin L., Fearns, Rachel, Chanda, Sushmita M., Blatt, Lawrence M., Symons, Julian A., Beigelman, Leo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476725/
https://www.ncbi.nlm.nih.gov/pubmed/26098424
http://dx.doi.org/10.1371/journal.ppat.1004995

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