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Inhibition of Donor-Reactive CD8+ T Cell Responses by Selective CD28 Blockade Is Independent of Reduced ICOS Expression

Programmed T cell differentiation is critically influenced by the complement of costimulatory and coinhibitory signals transmitted during initial antigen encounter. We previously showed that selective CD28 blockade with novel domain antibodies that leave CTLA-4-mediated coinhibitory signaling intact...

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Detalles Bibliográficos
Autores principales:	Liu, Danya, Suchard, Suzanne J., Nadler, Steve G., Ford, Mandy L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476729/ https://www.ncbi.nlm.nih.gov/pubmed/26098894 http://dx.doi.org/10.1371/journal.pone.0130490

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