Retrovirus-Mediated Expression of E2A-PBX1 Blocks Lymphoid Fate but Permits Retention of Myeloid Potential in Early Hematopoietic Progenitors

The oncogenic transcription factor E2A-PBX1 is expressed consequent to chromosomal translocation 1;19 and is an important oncogenic driver in cases of pre-B-cell acute lymphoblastic leukemia (ALL). Elucidating the mechanism by which E2A-PBX1 induces lymphoid leukemia would be expedited by the availa...

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Detalles Bibliográficos
Autores principales: Woodcroft, Mark W., Nanan, Kyster, Thompson, Patrick, Tyryshkin, Kathrin, Smith, Steven P., Slany, Robert K., LeBrun, David P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476730/
https://www.ncbi.nlm.nih.gov/pubmed/26098938
http://dx.doi.org/10.1371/journal.pone.0130495

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