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Tumor T(1) Relaxation Time for Assessing Response to Bevacizumab Anti-Angiogenic Therapy in a Mouse Ovarian Cancer Model

PURPOSE: To assess whether T(1) relaxation time of tumors may be used to assess response to bevacizumab anti-angiogenic therapy. Procedures: 12 female nude mice bearing subcutaneous SKOV3ip1-LC ovarian tumors were administered bevacizumab (6.25ug/g, n=6) or PBS (control, n=6) therapy twice a week fo...

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Detalles Bibliográficos
Autores principales: Ravoori, Murali K., Nishimura, Masato, Singh, Sheela P., Lu, Chunhua, Han, Lin, Hobbs, Brian P., Pradeep, Sunila, Choi, Hyun J., Bankson, James A., Sood, Anil K., Kundra, Vikas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476738/
https://www.ncbi.nlm.nih.gov/pubmed/26098849
http://dx.doi.org/10.1371/journal.pone.0131095
Descripción
Sumario:PURPOSE: To assess whether T(1) relaxation time of tumors may be used to assess response to bevacizumab anti-angiogenic therapy. Procedures: 12 female nude mice bearing subcutaneous SKOV3ip1-LC ovarian tumors were administered bevacizumab (6.25ug/g, n=6) or PBS (control, n=6) therapy twice a week for two weeks. T(1) maps of tumors were generated before, two days, and 2 weeks after initiating therapy. Tumor weight was assessed by MR and at necropsy. Histology for microvessel density, proliferation, and apoptosis was performed. RESULTS: Bevacizumab treatment resulted in tumor growth inhibition (p<0.04, n=6), confirming therapeutic efficacy. Tumor T(1) relaxation times increased in bevacizumab treated mice 2 days and 2 weeks after initiating therapy (p<.05, n=6). Microvessel density decreased 59% and cell proliferation (Ki67+) decreased 50% in the bevacizumab treatment group (p<.001, n=6), but not apoptosis. CONCLUSIONS: Findings suggest that increased tumor T(1) relaxation time is associated with response to bevacizumab therapy in ovarian cancer model and might serve as an early indicator of response.