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Paracetamol: a review with specific focus on the haemodynamic effects of intravenous administration
Paracetamol is one of the most commonly used drugs worldwide with non-prescription sales exceeding 25 thousand million doses per year in the United States of America. The haemodynamic effects of the intravenous paracetamol formulations are largely understudied. There is an emerging body of evidence...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
EDIMES Edizioni Internazionali Srl
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476766/ https://www.ncbi.nlm.nih.gov/pubmed/26157738 |
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author | Chiam, Elizabeth Weinberg, Laurence Bellomo, Rinaldo |
author_facet | Chiam, Elizabeth Weinberg, Laurence Bellomo, Rinaldo |
author_sort | Chiam, Elizabeth |
collection | PubMed |
description | Paracetamol is one of the most commonly used drugs worldwide with non-prescription sales exceeding 25 thousand million doses per year in the United States of America. The haemodynamic effects of the intravenous paracetamol formulations are largely understudied. There is an emerging body of evidence suggesting that intravenous paracetamol may cause iatrogenic hypotension. Little is known as to the mechanisms of this phenomenon or if intravenous paracetamol indeed does cause hypotension. As paracetamol has negligible solubility in aqueous solutions, many of the commercially available intravenous formulations contain mannitol (up to 3.91 g/100 mL paracetamol) as a stabilising ingredient. It is unknown if mannitol is a contributing factor in the observed hypotension. In this review, we outline the development of paracetamol’s current intravenous formulations, describe the composition of these formulations, and overview the literature pertaining to the proposed phenomenon of paracetamol-induced altered hypotension. Understanding the pharmacokinetic and pharmacodymanic properties of intravenous paracetamol may have important clinical implications for vulnerable patients in subgroups where haemodynamic stability is at risk such as those undergoing elective and emergency surgery. |
format | Online Article Text |
id | pubmed-4476766 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | EDIMES Edizioni Internazionali Srl |
record_format | MEDLINE/PubMed |
spelling | pubmed-44767662015-07-08 Paracetamol: a review with specific focus on the haemodynamic effects of intravenous administration Chiam, Elizabeth Weinberg, Laurence Bellomo, Rinaldo Heart Lung Vessel Review-Article Paracetamol is one of the most commonly used drugs worldwide with non-prescription sales exceeding 25 thousand million doses per year in the United States of America. The haemodynamic effects of the intravenous paracetamol formulations are largely understudied. There is an emerging body of evidence suggesting that intravenous paracetamol may cause iatrogenic hypotension. Little is known as to the mechanisms of this phenomenon or if intravenous paracetamol indeed does cause hypotension. As paracetamol has negligible solubility in aqueous solutions, many of the commercially available intravenous formulations contain mannitol (up to 3.91 g/100 mL paracetamol) as a stabilising ingredient. It is unknown if mannitol is a contributing factor in the observed hypotension. In this review, we outline the development of paracetamol’s current intravenous formulations, describe the composition of these formulations, and overview the literature pertaining to the proposed phenomenon of paracetamol-induced altered hypotension. Understanding the pharmacokinetic and pharmacodymanic properties of intravenous paracetamol may have important clinical implications for vulnerable patients in subgroups where haemodynamic stability is at risk such as those undergoing elective and emergency surgery. EDIMES Edizioni Internazionali Srl 2015 /pmc/articles/PMC4476766/ /pubmed/26157738 Text en Copyright © 2015, Heart, Lung and Vessels http://creativecommons.org/licenses/by-nc/3.0/ This article is distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review-Article Chiam, Elizabeth Weinberg, Laurence Bellomo, Rinaldo Paracetamol: a review with specific focus on the haemodynamic effects of intravenous administration |
title | Paracetamol: a review with specific focus on the haemodynamic effects of intravenous administration |
title_full | Paracetamol: a review with specific focus on the haemodynamic effects of intravenous administration |
title_fullStr | Paracetamol: a review with specific focus on the haemodynamic effects of intravenous administration |
title_full_unstemmed | Paracetamol: a review with specific focus on the haemodynamic effects of intravenous administration |
title_short | Paracetamol: a review with specific focus on the haemodynamic effects of intravenous administration |
title_sort | paracetamol: a review with specific focus on the haemodynamic effects of intravenous administration |
topic | Review-Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476766/ https://www.ncbi.nlm.nih.gov/pubmed/26157738 |
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