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Role of diet in prostate cancer: the epigenetic link

Diet is hypothesized to be a critical environmentally related risk factor for prostate cancer (PCa) development, and specific diets and dietary components can also affect PCa progression; however, the mechanisms underlying these associations remain elusive. As for a maturing organism, PCa's epi...

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Autores principales: Labbé, D P, Zadra, G, Ebot, E M, Mucci, L A, Kantoff, P W, Loda, M, Brown, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476943/
https://www.ncbi.nlm.nih.gov/pubmed/25531313
http://dx.doi.org/10.1038/onc.2014.422
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author Labbé, D P
Zadra, G
Ebot, E M
Mucci, L A
Kantoff, P W
Loda, M
Brown, M
author_facet Labbé, D P
Zadra, G
Ebot, E M
Mucci, L A
Kantoff, P W
Loda, M
Brown, M
author_sort Labbé, D P
collection PubMed
description Diet is hypothesized to be a critical environmentally related risk factor for prostate cancer (PCa) development, and specific diets and dietary components can also affect PCa progression; however, the mechanisms underlying these associations remain elusive. As for a maturing organism, PCa's epigenome is plastic and evolves from the pre-neoplastic to the metastatic stage. In particular, epigenetic remodeling relies on substrates or cofactors obtained from the diet. Here we review the evidence that bridges dietary modulation to alterations in the prostate epigenome. We propose that such diet-related effects offer a mechanistic link between the impact of different diets and the course of PCa development and progression.
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spelling pubmed-44769432016-03-03 Role of diet in prostate cancer: the epigenetic link Labbé, D P Zadra, G Ebot, E M Mucci, L A Kantoff, P W Loda, M Brown, M Oncogene Review Diet is hypothesized to be a critical environmentally related risk factor for prostate cancer (PCa) development, and specific diets and dietary components can also affect PCa progression; however, the mechanisms underlying these associations remain elusive. As for a maturing organism, PCa's epigenome is plastic and evolves from the pre-neoplastic to the metastatic stage. In particular, epigenetic remodeling relies on substrates or cofactors obtained from the diet. Here we review the evidence that bridges dietary modulation to alterations in the prostate epigenome. We propose that such diet-related effects offer a mechanistic link between the impact of different diets and the course of PCa development and progression. Nature Publishing Group 2015-09-03 2014-12-22 /pmc/articles/PMC4476943/ /pubmed/25531313 http://dx.doi.org/10.1038/onc.2014.422 Text en Copyright © 2015 Macmillan Publishers Limited http://creativecommons.org/licenses/by-nc-sa/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/
spellingShingle Review
Labbé, D P
Zadra, G
Ebot, E M
Mucci, L A
Kantoff, P W
Loda, M
Brown, M
Role of diet in prostate cancer: the epigenetic link
title Role of diet in prostate cancer: the epigenetic link
title_full Role of diet in prostate cancer: the epigenetic link
title_fullStr Role of diet in prostate cancer: the epigenetic link
title_full_unstemmed Role of diet in prostate cancer: the epigenetic link
title_short Role of diet in prostate cancer: the epigenetic link
title_sort role of diet in prostate cancer: the epigenetic link
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476943/
https://www.ncbi.nlm.nih.gov/pubmed/25531313
http://dx.doi.org/10.1038/onc.2014.422
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