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Immunomodulatory Role of Adipose-Derived Stem Cells on Equine Endometriosis

Endometriosis is a degenerative process due to a chronic inflammatory damage leading to extracellular matrix components deposition and glandular fibrosis. It is known that mesenchymal stem cells secrete a wide range of bioactive molecules, some of them modulating the immune inflammatory response, an...

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Detalles Bibliográficos
Autores principales: Falomo, Maria Elena, Ferroni, Letizia, Tocco, Ilaria, Gardin, Chiara, Zavan, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477049/
https://www.ncbi.nlm.nih.gov/pubmed/26180781
http://dx.doi.org/10.1155/2015/141485
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author Falomo, Maria Elena
Ferroni, Letizia
Tocco, Ilaria
Gardin, Chiara
Zavan, Barbara
author_facet Falomo, Maria Elena
Ferroni, Letizia
Tocco, Ilaria
Gardin, Chiara
Zavan, Barbara
author_sort Falomo, Maria Elena
collection PubMed
description Endometriosis is a degenerative process due to a chronic inflammatory damage leading to extracellular matrix components deposition and glandular fibrosis. It is known that mesenchymal stem cells secrete a wide range of bioactive molecules, some of them modulating the immune inflammatory response, and others providing regeneration and remodeling of injured tissue. We have performed in vitro experiments in order to analyze the capability of allogenic equine adipose-derived stem cells (ADSCs) to infiltrate mares' endometrial tissues and to stimulate the expression of cytokines and metallopeptidases. Differences in the biologic response to the exposure to ADSCs between pathological and healthy endometrial tissue have been identified. These results could challenge researchers to progress forward with future studies for the development of a biological therapy with a possible application in translational medicine.
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spelling pubmed-44770492015-07-15 Immunomodulatory Role of Adipose-Derived Stem Cells on Equine Endometriosis Falomo, Maria Elena Ferroni, Letizia Tocco, Ilaria Gardin, Chiara Zavan, Barbara Biomed Res Int Research Article Endometriosis is a degenerative process due to a chronic inflammatory damage leading to extracellular matrix components deposition and glandular fibrosis. It is known that mesenchymal stem cells secrete a wide range of bioactive molecules, some of them modulating the immune inflammatory response, and others providing regeneration and remodeling of injured tissue. We have performed in vitro experiments in order to analyze the capability of allogenic equine adipose-derived stem cells (ADSCs) to infiltrate mares' endometrial tissues and to stimulate the expression of cytokines and metallopeptidases. Differences in the biologic response to the exposure to ADSCs between pathological and healthy endometrial tissue have been identified. These results could challenge researchers to progress forward with future studies for the development of a biological therapy with a possible application in translational medicine. Hindawi Publishing Corporation 2015 2015-06-09 /pmc/articles/PMC4477049/ /pubmed/26180781 http://dx.doi.org/10.1155/2015/141485 Text en Copyright © 2015 Maria Elena Falomo et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Falomo, Maria Elena
Ferroni, Letizia
Tocco, Ilaria
Gardin, Chiara
Zavan, Barbara
Immunomodulatory Role of Adipose-Derived Stem Cells on Equine Endometriosis
title Immunomodulatory Role of Adipose-Derived Stem Cells on Equine Endometriosis
title_full Immunomodulatory Role of Adipose-Derived Stem Cells on Equine Endometriosis
title_fullStr Immunomodulatory Role of Adipose-Derived Stem Cells on Equine Endometriosis
title_full_unstemmed Immunomodulatory Role of Adipose-Derived Stem Cells on Equine Endometriosis
title_short Immunomodulatory Role of Adipose-Derived Stem Cells on Equine Endometriosis
title_sort immunomodulatory role of adipose-derived stem cells on equine endometriosis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477049/
https://www.ncbi.nlm.nih.gov/pubmed/26180781
http://dx.doi.org/10.1155/2015/141485
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