Severe Refractory Immune Thrombocytopenia Successfully Treated with High-Dose Pulse Cyclophosphamide and Eltrombopag

Severe refractory ITP is clinically challenging and a variety of single or combination chemotherapies have been tried with limited outcome. We report a case of ITP that was unresponsive to multiple agents including high-dose steroid, IVIG, Rho(D) immune globulin, rituximab, cyclosporine, azathioprin...

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Detalles Bibliográficos
Autores principales: Anwer, Faiz, Yun, Seongseok, Nair, Anju, Ahmad, Yusuf, Krishnadashan, Ravitharan, Deeg, H. Joachim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477130/
https://www.ncbi.nlm.nih.gov/pubmed/26180646
http://dx.doi.org/10.1155/2015/583451
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author Anwer, Faiz
Yun, Seongseok
Nair, Anju
Ahmad, Yusuf
Krishnadashan, Ravitharan
Deeg, H. Joachim
author_facet Anwer, Faiz
Yun, Seongseok
Nair, Anju
Ahmad, Yusuf
Krishnadashan, Ravitharan
Deeg, H. Joachim
author_sort Anwer, Faiz
collection PubMed
description Severe refractory ITP is clinically challenging and a variety of single or combination chemotherapies have been tried with limited outcome. We report a case of ITP that was unresponsive to multiple agents including high-dose steroid, IVIG, Rho(D) immune globulin, rituximab, cyclosporine, azathioprine, vincristine, mycophenolate mofetil, romiplostim, and eltrombopag; however, it achieved complete remission with combination treatment of cyclophosphamide and eltrombopag.
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spelling pubmed-44771302015-07-15 Severe Refractory Immune Thrombocytopenia Successfully Treated with High-Dose Pulse Cyclophosphamide and Eltrombopag Anwer, Faiz Yun, Seongseok Nair, Anju Ahmad, Yusuf Krishnadashan, Ravitharan Deeg, H. Joachim Case Rep Hematol Case Report Severe refractory ITP is clinically challenging and a variety of single or combination chemotherapies have been tried with limited outcome. We report a case of ITP that was unresponsive to multiple agents including high-dose steroid, IVIG, Rho(D) immune globulin, rituximab, cyclosporine, azathioprine, vincristine, mycophenolate mofetil, romiplostim, and eltrombopag; however, it achieved complete remission with combination treatment of cyclophosphamide and eltrombopag. Hindawi Publishing Corporation 2015 2015-06-09 /pmc/articles/PMC4477130/ /pubmed/26180646 http://dx.doi.org/10.1155/2015/583451 Text en Copyright © 2015 Faiz Anwer et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Anwer, Faiz
Yun, Seongseok
Nair, Anju
Ahmad, Yusuf
Krishnadashan, Ravitharan
Deeg, H. Joachim
Severe Refractory Immune Thrombocytopenia Successfully Treated with High-Dose Pulse Cyclophosphamide and Eltrombopag
title Severe Refractory Immune Thrombocytopenia Successfully Treated with High-Dose Pulse Cyclophosphamide and Eltrombopag
title_full Severe Refractory Immune Thrombocytopenia Successfully Treated with High-Dose Pulse Cyclophosphamide and Eltrombopag
title_fullStr Severe Refractory Immune Thrombocytopenia Successfully Treated with High-Dose Pulse Cyclophosphamide and Eltrombopag
title_full_unstemmed Severe Refractory Immune Thrombocytopenia Successfully Treated with High-Dose Pulse Cyclophosphamide and Eltrombopag
title_short Severe Refractory Immune Thrombocytopenia Successfully Treated with High-Dose Pulse Cyclophosphamide and Eltrombopag
title_sort severe refractory immune thrombocytopenia successfully treated with high-dose pulse cyclophosphamide and eltrombopag
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477130/
https://www.ncbi.nlm.nih.gov/pubmed/26180646
http://dx.doi.org/10.1155/2015/583451
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