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Metabolomics reveals impaired maturation of HDL particles in adolescents with hyperinsulinaemic androgen excess
Hyperinsulinaemic androgen excess (HIAE) in prepubertal and pubertal girls usually precedes a broader pathological phenotype in adulthood that is associated with anovulatory infertility, metabolic syndrome and type 2 diabetes. The metabolic derangements that determine these long-term health risks re...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477239/ https://www.ncbi.nlm.nih.gov/pubmed/26099471 http://dx.doi.org/10.1038/srep11496 |
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author | Samino, Sara Vinaixa, Maria Díaz, Marta Beltran, Antoni Rodríguez, Miguel A. Mallol, Roger Heras, Mercedes Cabre, Anna Garcia, Lorena Canela, Nuria de Zegher, Francis Correig, Xavier Ibáñez, Lourdes Yanes, Oscar |
author_facet | Samino, Sara Vinaixa, Maria Díaz, Marta Beltran, Antoni Rodríguez, Miguel A. Mallol, Roger Heras, Mercedes Cabre, Anna Garcia, Lorena Canela, Nuria de Zegher, Francis Correig, Xavier Ibáñez, Lourdes Yanes, Oscar |
author_sort | Samino, Sara |
collection | PubMed |
description | Hyperinsulinaemic androgen excess (HIAE) in prepubertal and pubertal girls usually precedes a broader pathological phenotype in adulthood that is associated with anovulatory infertility, metabolic syndrome and type 2 diabetes. The metabolic derangements that determine these long-term health risks remain to be clarified. Here we use NMR and MS-based metabolomics to show that serum levels of methionine sulfoxide in HIAE girls are an indicator of the degree of oxidation of methionine-148 residue in apolipoprotein-A1. Oxidation of apo-A1 in methionine-148, in turn, leads to an impaired maturation of high-density lipoproteins (HDL) that is reflected in a decline of large HDL particles. Notably, such metabolic alterations occur in the absence of impaired glucose tolerance, hyperglycemia and hypertriglyceridemia, and were partially restored after 18 months of treatment with a low-dose combination of pioglitazone, metformin and flutamide. |
format | Online Article Text |
id | pubmed-4477239 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-44772392015-06-24 Metabolomics reveals impaired maturation of HDL particles in adolescents with hyperinsulinaemic androgen excess Samino, Sara Vinaixa, Maria Díaz, Marta Beltran, Antoni Rodríguez, Miguel A. Mallol, Roger Heras, Mercedes Cabre, Anna Garcia, Lorena Canela, Nuria de Zegher, Francis Correig, Xavier Ibáñez, Lourdes Yanes, Oscar Sci Rep Article Hyperinsulinaemic androgen excess (HIAE) in prepubertal and pubertal girls usually precedes a broader pathological phenotype in adulthood that is associated with anovulatory infertility, metabolic syndrome and type 2 diabetes. The metabolic derangements that determine these long-term health risks remain to be clarified. Here we use NMR and MS-based metabolomics to show that serum levels of methionine sulfoxide in HIAE girls are an indicator of the degree of oxidation of methionine-148 residue in apolipoprotein-A1. Oxidation of apo-A1 in methionine-148, in turn, leads to an impaired maturation of high-density lipoproteins (HDL) that is reflected in a decline of large HDL particles. Notably, such metabolic alterations occur in the absence of impaired glucose tolerance, hyperglycemia and hypertriglyceridemia, and were partially restored after 18 months of treatment with a low-dose combination of pioglitazone, metformin and flutamide. Nature Publishing Group 2015-06-23 /pmc/articles/PMC4477239/ /pubmed/26099471 http://dx.doi.org/10.1038/srep11496 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Samino, Sara Vinaixa, Maria Díaz, Marta Beltran, Antoni Rodríguez, Miguel A. Mallol, Roger Heras, Mercedes Cabre, Anna Garcia, Lorena Canela, Nuria de Zegher, Francis Correig, Xavier Ibáñez, Lourdes Yanes, Oscar Metabolomics reveals impaired maturation of HDL particles in adolescents with hyperinsulinaemic androgen excess |
title | Metabolomics reveals impaired maturation of HDL particles in adolescents with hyperinsulinaemic androgen excess |
title_full | Metabolomics reveals impaired maturation of HDL particles in adolescents with hyperinsulinaemic androgen excess |
title_fullStr | Metabolomics reveals impaired maturation of HDL particles in adolescents with hyperinsulinaemic androgen excess |
title_full_unstemmed | Metabolomics reveals impaired maturation of HDL particles in adolescents with hyperinsulinaemic androgen excess |
title_short | Metabolomics reveals impaired maturation of HDL particles in adolescents with hyperinsulinaemic androgen excess |
title_sort | metabolomics reveals impaired maturation of hdl particles in adolescents with hyperinsulinaemic androgen excess |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477239/ https://www.ncbi.nlm.nih.gov/pubmed/26099471 http://dx.doi.org/10.1038/srep11496 |
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