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Flaxseed Oil Containing α-Linolenic Acid Ester of Plant Sterol Improved Atherosclerosis in ApoE Deficient Mice

Plant sterols (PS) have potential preventive function in atherosclerosis due to their cholesterol-lowering ability. Dietary α-linolenic acid in flaxseed oil is associated with a reduction in cardiovascular events through its hypolipidemic and anti-inflammation properties. This study was designed to...

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Autores principales: Han, Hao, Yan, Peipei, Chen, Li, Luo, Cheng, Gao, Hui, Deng, Qianchun, Zheng, Mingming, Shi, Yong, Liu, Liegang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477243/
https://www.ncbi.nlm.nih.gov/pubmed/26180602
http://dx.doi.org/10.1155/2015/958217
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author Han, Hao
Yan, Peipei
Chen, Li
Luo, Cheng
Gao, Hui
Deng, Qianchun
Zheng, Mingming
Shi, Yong
Liu, Liegang
author_facet Han, Hao
Yan, Peipei
Chen, Li
Luo, Cheng
Gao, Hui
Deng, Qianchun
Zheng, Mingming
Shi, Yong
Liu, Liegang
author_sort Han, Hao
collection PubMed
description Plant sterols (PS) have potential preventive function in atherosclerosis due to their cholesterol-lowering ability. Dietary α-linolenic acid in flaxseed oil is associated with a reduction in cardiovascular events through its hypolipidemic and anti-inflammation properties. This study was designed to evaluate the effects of flaxseed oil containing α-linolenic acid ester of PS (ALA-PS) on atherosclerosis and investigate the underlying mechanisms. C57BL/6 mice were administered a regular diet and apoE knockout (apoE-KO) mice were given a high fat diet alone or supplemented with 5% flaxseed oil with or without 3.3% ALA-PS for 18 weeks. Results demonstrated that flaxseed oil containing ALA-PS was synergistically interaction in ameliorating atherosclerosis as well as optimizing overall lipid levels, inhibiting inflammation and reducing oxidative stress. These data were associated with the modification effects on expression levels of genes involved in lipid metabolism (PPARα, HMGCR, and SREBPs), inflammation (IL-6, TNF, MCP-1, and VCAM-1), and oxidative stress (NADPH oxidase).
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spelling pubmed-44772432015-07-15 Flaxseed Oil Containing α-Linolenic Acid Ester of Plant Sterol Improved Atherosclerosis in ApoE Deficient Mice Han, Hao Yan, Peipei Chen, Li Luo, Cheng Gao, Hui Deng, Qianchun Zheng, Mingming Shi, Yong Liu, Liegang Oxid Med Cell Longev Research Article Plant sterols (PS) have potential preventive function in atherosclerosis due to their cholesterol-lowering ability. Dietary α-linolenic acid in flaxseed oil is associated with a reduction in cardiovascular events through its hypolipidemic and anti-inflammation properties. This study was designed to evaluate the effects of flaxseed oil containing α-linolenic acid ester of PS (ALA-PS) on atherosclerosis and investigate the underlying mechanisms. C57BL/6 mice were administered a regular diet and apoE knockout (apoE-KO) mice were given a high fat diet alone or supplemented with 5% flaxseed oil with or without 3.3% ALA-PS for 18 weeks. Results demonstrated that flaxseed oil containing ALA-PS was synergistically interaction in ameliorating atherosclerosis as well as optimizing overall lipid levels, inhibiting inflammation and reducing oxidative stress. These data were associated with the modification effects on expression levels of genes involved in lipid metabolism (PPARα, HMGCR, and SREBPs), inflammation (IL-6, TNF, MCP-1, and VCAM-1), and oxidative stress (NADPH oxidase). Hindawi Publishing Corporation 2015 2015-06-09 /pmc/articles/PMC4477243/ /pubmed/26180602 http://dx.doi.org/10.1155/2015/958217 Text en Copyright © 2015 Hao Han et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Han, Hao
Yan, Peipei
Chen, Li
Luo, Cheng
Gao, Hui
Deng, Qianchun
Zheng, Mingming
Shi, Yong
Liu, Liegang
Flaxseed Oil Containing α-Linolenic Acid Ester of Plant Sterol Improved Atherosclerosis in ApoE Deficient Mice
title Flaxseed Oil Containing α-Linolenic Acid Ester of Plant Sterol Improved Atherosclerosis in ApoE Deficient Mice
title_full Flaxseed Oil Containing α-Linolenic Acid Ester of Plant Sterol Improved Atherosclerosis in ApoE Deficient Mice
title_fullStr Flaxseed Oil Containing α-Linolenic Acid Ester of Plant Sterol Improved Atherosclerosis in ApoE Deficient Mice
title_full_unstemmed Flaxseed Oil Containing α-Linolenic Acid Ester of Plant Sterol Improved Atherosclerosis in ApoE Deficient Mice
title_short Flaxseed Oil Containing α-Linolenic Acid Ester of Plant Sterol Improved Atherosclerosis in ApoE Deficient Mice
title_sort flaxseed oil containing α-linolenic acid ester of plant sterol improved atherosclerosis in apoe deficient mice
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477243/
https://www.ncbi.nlm.nih.gov/pubmed/26180602
http://dx.doi.org/10.1155/2015/958217
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