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Significance of KRAS/PAK1/Crk pathway in non-small cell lung cancer oncogenesis

BACKGROUND: Key effector(s) of mutated KRAS in lung cancer progression and metastasis are unknown. Here we investigated the role of PAK1/Crk axis in transduction of the oncogenic KRAS signal in non-small cell lung cancer (NSCLC). METHODS: We used NSCLC clinical specimens to examine the correlation a...

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Detalles Bibliográficos
Autores principales:	Mortazavi, Fariborz, Lu, Jie, Phan, Ryan, Lewis, Michael, Trinidad, Kenny, Aljilani, Amir, Pezeshkpour, Gholamhossein, Tamanoi, Fuyuhiko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477307/ https://www.ncbi.nlm.nih.gov/pubmed/25956913 http://dx.doi.org/10.1186/s12885-015-1360-4

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