An integrated approach to reveal miRNAs’ impacts on the functional consequence of copy number alterations in cancer

Copy number alteration (CNA) is known to induce gene expression changes mainly through dosage effect, and therefore affect the initiation and progression of tumor. However, tumor samples exhibit heterogeneity in gene dosage sensitivity due to the complicated mechanisms of transcriptional regulation....

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Detalles Bibliográficos
Autores principales: Li, Kening, Liu, Yongjing, Zhou, Yuanshuai, Zhang, Rui, Zhao, Ning, Yan, Zichuang, Zhang, Qiang, Zhang, Shujuan, Qiu, Fujun, Xu, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477324/
https://www.ncbi.nlm.nih.gov/pubmed/26099552
http://dx.doi.org/10.1038/srep11567

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