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Cellular Stress, Excessive Apoptosis, and the Effect of Metformin in a Mouse Model of Type 2 Diabetic Embryopathy

Increasing prevalence of type 2 diabetes in women of childbearing age has led to a higher incidence of diabetes-associated birth defects. We established a model of type 2 diabetic embryopathy by feeding 4-week-old female mice a high-fat diet (HFD) (60% fat). After 15 weeks on HFD, the mice showed ch...

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Detalles Bibliográficos
Autores principales:	Wu, Yanqing, Wang, Fang, Fu, Mao, Wang, Cheng, Quon, Michael J., Yang, Peixin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2015
Materias:	Pathophysiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477360/ https://www.ncbi.nlm.nih.gov/pubmed/25720389 http://dx.doi.org/10.2337/db14-1683

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