Cargando…

Hepato-protective effect of rutin via IL-6/STAT3 pathway in CCl(4)-induced hepatotoxicity in rats

BACKGROUND: Carbon tetrachloride (CCl(4)) induces hepatotoxicity in animal models, including the increased blood flow and cytokine accumulation that are characteristic of tissue inflammation. The present study investigates the hepato-protective effect of rutin on CCl(4)-induced hepatotoxicity in rat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hafez, Mohamed M., Al-Harbi, Naif O., Al-Hoshani, Ali Rashed, Al-hosaini, Khaled A., Al Shrari, Shakir D., Al Rejaie, Salim S., Sayed-Ahmed, Mohamed M., Al-Shabanah, Othman A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477598/ https://www.ncbi.nlm.nih.gov/pubmed/26062544 http://dx.doi.org/10.1186/s40659-015-0022-y

Ejemplares similares

Association between Paraoxonases Gene Expression and Oxidative Stress in Hepatotoxicity Induced by CCl(4)
por: Hafez, Mohamed M., et al.
Publicado: (2014)

Rutin Attenuates Hepatotoxicity in High-Cholesterol-Diet-Fed Rats
por: AlSharari, Shakir D., et al.
Publicado: (2016)

Effect of ginseng extract on the TGF-β1 signaling pathway in CCl(4)-induced liver fibrosis in rats
por: Hafez, Mohamed M., et al.
Publicado: (2017)

Protective effect of rutin on the antioxidant genes expression in hypercholestrolemic male Westar rat
por: Al-Rejaie, Salem S, et al.
Publicado: (2013)

Downregulation of Oxidative and Nitrosative Apoptotic Signaling by L-Carnitine in Ifosfamide-Induced Fanconi Syndrome Rat Model
por: Sayed-Ahmed, Mohamed M., et al.
Publicado: (2012)

Neuro-protective effect of rutin against Cisplatin-induced neurotoxic rat model
por: Almutairi, Mashal M., et al.
Publicado: (2017)

Protective effect of rutin supplementation against cisplatin-induced Nephrotoxicity in rats
por: Alhoshani, Ali R., et al.
Publicado: (2017)

Anti-metastatic and anti-proliferative activity of eugenol against triple negative and HER2 positive breast cancer cells
por: Abdullah, Mashan L., et al.
Publicado: (2018)

Desferrioxamine Attenuates Doxorubicin-Induced Acute Cardiotoxicity through TFG-β/Smad p53 Pathway in Rat Model
por: Al-Shabanah, Othman A., et al.
Publicado: (2012)

Thymoquinone attenuates diethylnitrosamine induction of hepatic carcinogenesis through antioxidant signaling
por: Sayed-Ahmed, Mohamed M, et al.
Publicado: (2010)

Human papillomavirus genotyping and integration in ovarian cancer Saudi patients
por: Al-Shabanah, Othman A, et al.
Publicado: (2013)

Doxorubicin Toxicity can be Ameliorated during Antioxidant L-Carnitine Supplementation
por: Alshabanah, Othman A., et al.
Publicado: (2010)

Inhibitory Effect of Ginseng on Breast Cancer Cell Line Growth Via Up-Regulation of Cyclin Dependent Kinase Inhibitor, p21 and p53
por: AL Shabanah, Othman A, et al.
Publicado: (2016)

Alleviating effects of morin against experimentally-induced diabetic osteopenia
por: Abuohashish, Hatem M, et al.
Publicado: (2013)

Inhibition of Gene Expression of Organic Cation/Carnitine Transporter and Antioxidant Enzymes in Oxazaphosphorines-Induced Acute Cardiomyopathic Rat Models
por: Sayed-Ahmed, Mohamed M., et al.
Publicado: (2012)

Characterization of Apoptosis in a Breast Cancer Cell Line after IL-10 Silencing
por: Alotaibi, Moureq R, et al.
Publicado: (2018)

LCZ696 Protects against Diabetic Cardiomyopathy-Induced Myocardial Inflammation, ER Stress, and Apoptosis through Inhibiting AGEs/NF-κB and PERK/CHOP Signaling Pathways
por: Belali, Osamah M., et al.
Publicado: (2022)

Metallothionein induction reduces caspase-3 activity and TNFα levels with preservation of cognitive function and intact hippocampal neurons in carmustine-treated rats
por: Helal, Gouda K, et al.
Publicado: (2009)

Eugenol-Induced Autophagy and Apoptosis in Breast Cancer Cells via PI3K/AKT/FOXO3a Pathway Inhibition
por: Abdullah, Mashan L., et al.
Publicado: (2021)

Carnitine Supplementation Attenuates Sunitinib-Induced Inhibition of AMP-Activated Protein Kinase Downstream Signals in Cardiac Tissues
por: Sayed-Ahmed, Mohamed M., et al.
Publicado: (2019)

Gender difference following high cholesterol diet induced renal injury and the protective role of rutin and ascorbic acid combination in Wistar albino rats
por: Al-Rejaie, Salim Salih, et al.
Publicado: (2012)

Angiotensin II receptor Neprilysin inhibitor (LCZ696) compared to Valsartan attenuates Hepatotoxicity in STZ-induced hyperglycemic rats
por: Alqahtani, Faleh, et al.
Publicado: (2020)

An up-to-date review of rutin and its biological and pharmacological activities
por: Al-Dhabi, Naif Abdullah, et al.
Publicado: (2015)

The relevance of nanotechnology, hepato-protective agents in reducing the toxicity and augmenting the bioavailability of isotretinoin
por: Hosny, Khaled M., et al.
Publicado: (2020)

Amelioration of CCl(4)-Induced Hepatotoxicity in Rabbits by Lepidium sativum Seeds
por: Zamzami, Mazin A., et al.
Publicado: (2019)

Protective effect of Apremilast against LPS-induced acute lung injury via modulation of oxidative stress and inflammation
por: Al-Harbi, Naif O., et al.
Publicado: (2022)

Among 45 variants in 11 genes, HDM2 promoter polymorphisms emerge as new candidate biomarker associated with radiation toxicity
por: Alsbeih, Ghazi, et al.
Publicado: (2013)

Simultaneous Determination of Different Polyamines and their Mono-Acetylated Derivatives in Gastric Tissue by HPLC with Post-Column Derivatization
por: Raza, Muhammad, et al.
Publicado: (2010)

Molecular Mechanistic Pathways Targeted by Natural Antioxidants in the Prevention and Treatment of Chronic Kidney Disease
por: Mohany, Mohamed, et al.
Publicado: (2021)

The Role of NF-κB and Bax/Bcl-2/Caspase-3 Signaling Pathways in the Protective Effects of Sacubitril/Valsartan (Entresto) against HFD/STZ-Induced Diabetic Kidney Disease
por: Mohany, Mohamed, et al.
Publicado: (2022)

CCl(4)-induced hepatotoxicity: protective effect of rutin on p53, CYP2E1 and the antioxidative status in rat
por: Khan, Rahmat A, et al.
Publicado: (2012)

Tricho-hepato-enteric syndrome: Retrospective multicenter experience in Saudi Arabia
por: Alsaleem, Badr M., et al.
Publicado: (2021)

Evaluation of antiproteinuric and hepato-renal protective activities of propolis in paracetamol toxicity in rats
por: El Menyiy, Nawal, et al.
Publicado: (2018)

Adipose tissue expression of CCL19 chemokine is positively associated with insulin resistance
por: Kochumon, Shihab, et al.
Publicado: (2018)

Therapeutic efficacy of ethanolic extract of Aerva javanica aerial parts in the amelioration of CCl(4)-induced hepatotoxicity and oxidative damage in rats
por: Arbab, Ahmed H., et al.
Publicado: (2016)

Protective role of Dodonaea viscosa extract against streptozotocin-induced hepatotoxicity and nephrotoxicity in rats
por: Alanazi, Ahmed Z., et al.
Publicado: (2023)

The hepatoprotective activity of olive oil and Nigella sativa oil against CCl(4) induced hepatotoxicity in male rats
por: Al-Seeni, Madeha N., et al.
Publicado: (2016)

Telmisartan inhibits hyperalgesia and inflammatory progression in a diabetic neuropathic pain model of Wistar rats
por: Al-Rejaie, Salim S., et al.
Publicado: (2015)

Persea americana extract protects intestinal tissue from Eimeria papillata-induced murine Infection
por: Alajmi, Fatemah, et al.
Publicado: (2023)

Correction: Utility of Dexrazoxane for the Attenuation of Epirubicin-Induced Genetic Alterations in Mouse Germ Cells
por: Attia, Sabry M., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_rkoeucfvado2rcljpk2b80arn8