Cargando…

N-Myristoyltransferase Is a Cell Wall Target in Aspergillus fumigatus

[Image: see text] Treatment of filamentous fungal infections relies on a limited repertoire of antifungal agents. Compounds possessing novel modes of action are urgently required. N-myristoylation is a ubiquitous modification of eukaryotic proteins. The enzyme N-myristoyltransferase (NMT) has been c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fang, Wenxia, Robinson, David A., Raimi, Olawale G., Blair, David E., Harrison, Justin R., Lockhart, Deborah E. A., Torrie, Leah S., Ruda, Gian Filippo, Wyatt, Paul G., Gilbert, Ian H., van Aalten, Daan M. F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2015
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477619/ https://www.ncbi.nlm.nih.gov/pubmed/25706802 http://dx.doi.org/10.1021/cb5008647

Ejemplares similares

Phosphoglucose Isomerase Is Important for Aspergillus fumigatus Cell Wall Biogenesis
por: Zhou, Yao, et al.
Publicado: (2022)

Genetic validation of Aspergillus fumigatus phosphoglucomutase as a viable therapeutic target in invasive aspergillosis
por: Yan, Kaizhou, et al.
Publicado: (2022)

Screening-based discovery of Aspergillus fumigatus plant-type chitinase inhibitors
por: Lockhart, Deborah E.A., et al.
Publicado: (2014)

Genetic and structural validation of Aspergillus fumigatus UDP-N-acetylglucosamine pyrophosphorylase as an antifungal target
por: Fang, Wenxia, et al.
Publicado: (2013)

Genetic and structural validation of Aspergillus fumigatus N-acetylphosphoglucosamine mutase as an antifungal target
por: Fang, Wenxia, et al.
Publicado: (2013)

N-Myristoyltransferase inhibitors as new leads to treat sleeping sickness
por: Frearson, Julie A., et al.
Publicado: (2010)

Purification, crystallization and preliminary X-ray diffraction data of UDP-galactopyranose mutase from Aspergillus fumigatus
por: Penman, George A., et al.
Publicado: (2012)

Mechanisms of redundancy and specificity of the Aspergillus fumigatus Crh transglycosylases
por: Fang, Wenxia, et al.
Publicado: (2019)

Biochemical and genetic characterization of Trypanosoma cruzi N-myristoyltransferase
por: Roberts, Adam J., et al.
Publicado: (2014)

Design and Synthesis of Brain Penetrant Trypanocidal N-Myristoyltransferase Inhibitors
por: Bayliss, Tracy, et al.
Publicado: (2017)

Targeting a critical step in fungal hexosamine biosynthesis
por: Lockhart, Deborah E. A., et al.
Publicado: (2020)

Pharmacological Validation of N-Myristoyltransferase as a Drug Target in Leishmania donovani
por: Corpas-Lopez, Victoriano, et al.
Publicado: (2018)

Evidence for substrate-assisted catalysis in N-acetylphosphoglucosamine mutase
por: Raimi, Olawale G., et al.
Publicado: (2018)

A missense mutation in a patient with developmental delay affects the activity and structure of the hexosamine biosynthetic pathway enzyme AGX1
por: Chen, Xiping, et al.
Publicado: (2020)

Discovery of a Novel Class of Orally Active Trypanocidal N-Myristoyltransferase Inhibitors
por: Brand, Stephen, et al.
Publicado: (2011)

Lead Optimization of a Pyrazole Sulfonamide Series of Trypanosoma bruceiN-Myristoyltransferase Inhibitors: Identification and Evaluation of CNS Penetrant Compounds as Potential Treatments for Stage 2 Human African Trypanosomiasis
por: Brand, Stephen, et al.
Publicado: (2014)

A Molecular Hybridization Approach for the Design of Potent, Highly Selective, and Brain-Penetrant N-Myristoyltransferase Inhibitors
por: Harrison, Justin R., et al.
Publicado: (2018)

Development of Small-Molecule Trypanosoma brucei N-Myristoyltransferase Inhibitors: Discovery and Optimisation of a Novel Binding Mode
por: Spinks, Daniel, et al.
Publicado: (2015)

Identification and structure solution of fragment hits against kinetoplastid N-myristoyltransferase
por: Robinson, David A., et al.
Publicado: (2015)

N-Myristoyltransferase, a Potential Antifungal Candidate Drug-Target for Aspergillus flavus
por: Wang, Yu, et al.
Publicado: (2022)

Aspergillus nidulans Cell Wall Composition and Function Change in Response to Hosting Several Aspergillus fumigatus UDP-Galactopyranose Mutase Activity Mutants
por: Alam, Md Kausar, et al.
Publicado: (2014)

Microbe Profile: Aspergillus fumigatus: a saprotrophic and opportunistic fungal pathogen
por: Fang, Wenxia, et al.
Publicado: (2018)

Melanin is an essential component for the integrity of the cell wall of Aspergillus fumigatus conidia
por: Pihet, Marc, et al.
Publicado: (2009)

Azole-induced cell wall carbohydrate patches kill Aspergillus fumigatus
por: Geißel, Bernadette, et al.
Publicado: (2018)

Aspergillus fumigatus—Host Interactions Mediating Airway Wall Remodelling in Asthma
por: Namvar, Sara, et al.
Publicado: (2022)

Hinokitiol inhibits Aspergillus fumigatus by interfering with the cell membrane and cell wall
por: Meng, Fanyue, et al.
Publicado: (2023)

Recognition of a glycosylation substrate by the O-GlcNAc transferase TPR repeats
por: Rafie, Karim, et al.
Publicado: (2017)

Aspergillus fumigatus in Poultry
por: Arné, Pascal, et al.
Publicado: (2011)

Azole-Resistant Aspergillus fumigatus, Iran
por: Seyedmousavi, Seyedmojtaba, et al.
Publicado: (2013)

Discovery and characterization of novel Aspergillus fumigatus mycoviruses
por: Zoll, Jan, et al.
Publicado: (2018)

Aspergillus fumigatus Mitochondrial Acetyl Coenzyme A Acetyltransferase as an Antifungal Target
por: Zhang, Yuanwei, et al.
Publicado: (2020)

Regulation of Development in Aspergillus nidulans and Aspergillus fumigatus
por: Yu, Jae-Hyuk
Publicado: (2010)

Receptor-mediated signaling in Aspergillus fumigatus
por: Grice, C. M., et al.
Publicado: (2013)

Ecology of aspergillosis: insights into the pathogenic potency of Aspergillus fumigatus and some other Aspergillus species
por: Paulussen, Caroline, et al.
Publicado: (2016)

Genomic Diversity of Azole-Resistant Aspergillus fumigatus in the United States
por: Etienne, Kizee A., et al.
Publicado: (2021)

Species-Specific Immunological Reactivities Depend on the Cell-Wall Organization of the Two Aspergillus, Aspergillus fumigatus and A. flavus
por: Wong, Sarah Sze Wah, et al.
Publicado: (2021)

Antioxidant Activity of Aspergillus fumigatus
por: Arora, Daljit Singh, et al.
Publicado: (2011)

Role of Hydrophobins in Aspergillus fumigatus
por: Valsecchi, Isabel, et al.
Publicado: (2017)

SENSITIZATION TO ASPERGILLUS FUMIGATUS IN FIBROCYSTICS
por: Rosario, Nelson A., et al.
Publicado: (2018)

Culturing and Mating of Aspergillus fumigatus
por: Ashton, George D., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_lgckbqerv3e0p1hlbrtq8taiqa