An HDAC2-TET1 switch at distinct chromatin regions significantly promotes the maturation of pre-iPS to iPS cells

The maturation of induced pluripotent stem cells (iPS) is one of the limiting steps of somatic cell reprogramming, but the underlying mechanism is largely unknown. Here, we reported that knockdown of histone deacetylase 2 (HDAC2) specifically promoted the maturation of iPS cells. Further studies sho...

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Detalles Bibliográficos
Autores principales: Wei, Tingyi, Chen, Wen, Wang, Xiukun, Zhang, Man, Chen, Jiayu, Zhu, Songcheng, Chen, Long, Yang, Dandan, Wang, Guiying, Jia, Wenwen, Yu, Yangyang, Duan, Tao, Wu, Minjuan, Liu, Houqi, Gao, Shaorong, Kang, Jiuhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477660/
https://www.ncbi.nlm.nih.gov/pubmed/25934799
http://dx.doi.org/10.1093/nar/gkv430

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