CDK-mediated RNF4 phosphorylation regulates homologous recombination in S-phase

There are the two major pathways responsible for the repair of DNA double-strand breaks (DSBs): non-homologous end-joining (NHEJ) and homologous recombination (HR). NHEJ operates throughout the cell-cycle, while HR is primarily active in the S/G2 phases suggesting that there are cell cycle-specific...

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Detalles Bibliográficos
Autores principales: Luo, Kuntian, Deng, Min, Li, Yunhui, Wu, Chenming, Xu, Ziwen, Yuan, Jian, Lou, Zhenkun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477664/
https://www.ncbi.nlm.nih.gov/pubmed/25948581
http://dx.doi.org/10.1093/nar/gkv434

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