TREM2 lipid sensing sustains microglia response in an Alzheimer’s disease model

Triggering receptor expressed on myeloid cells 2 (TREM2) is a microglia surface receptor that triggers intracellular protein tyrosine phosphorylation. Recent genome-wide association studies have shown that a rare R47H mutation of TREM2 correlates with a substantial increase in the risk of developing...

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Detalles Bibliográficos
Autores principales: Wang, Yaming, Cella, Marina, Mallinson, Kaitlin, Ulrich, Jason D., Young, Katherine L., Robinette, Michelle L., Gifillian, Susan, Krishnan, Gokul M., Sudhakar, Shwetha, Zinselmeyer, Bernd H., Holtzman, David M., Cirrito, John R., Colonna, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477963/
https://www.ncbi.nlm.nih.gov/pubmed/25728668
http://dx.doi.org/10.1016/j.cell.2015.01.049

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