Cargando…

IgG4-Associated Cholangitis Can Mimic Hilar Cholangiocarcinoma

IgG4-associated cholangitis can mimic hilar cholangiocarcinoma. Previously reported patients with IgG4-associated cholangitis mimicking cholangiocarcinoma had elevated serum IgG4 levels and long-segment biliary strictures. However, in the absence of other diagnostic criteria for malignancy, IgG4-ass...

Descripción completa

Detalles Bibliográficos
Autores principales: Zaydfudim, Victor M., Wang, Andrew Y., de Lange, Eduard E., Zhao, Zimin, Moskaluk, Christopher A., Bauer, Todd W., Adams, Reid B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Gut and Liver 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4478001/
https://www.ncbi.nlm.nih.gov/pubmed/26033685
http://dx.doi.org/10.5009/gnl14241
_version_ 1782377838553333760
author Zaydfudim, Victor M.
Wang, Andrew Y.
de Lange, Eduard E.
Zhao, Zimin
Moskaluk, Christopher A.
Bauer, Todd W.
Adams, Reid B.
author_facet Zaydfudim, Victor M.
Wang, Andrew Y.
de Lange, Eduard E.
Zhao, Zimin
Moskaluk, Christopher A.
Bauer, Todd W.
Adams, Reid B.
author_sort Zaydfudim, Victor M.
collection PubMed
description IgG4-associated cholangitis can mimic hilar cholangiocarcinoma. Previously reported patients with IgG4-associated cholangitis mimicking cholangiocarcinoma had elevated serum IgG4 levels and long-segment biliary strictures. However, in the absence of other diagnostic criteria for malignancy, IgG4-associated cholangitis should remain a consideration among patients with normal serum IgG4 and a hilar mass suspicious for cholangiocarcinoma. The presence of a hilar mass and a malignant-appearing biliary stricture in two patients with normal serum IgG4 prompted further evaluation and subsequent concomitant liver and bile duct resection and reconstruction. The diagnosis of IgG4-associated cholangitis was established during the pathologic evaluation of the resected specimens. IgG4-associated cholangitis is a known imitator of hilar cholangiocarcinoma and should be considered in the differential diagnosis even among serologically IgG4-negative patients with a hilar mass prior to operative resection.
format Online
Article
Text
id pubmed-4478001
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Gut and Liver
record_format MEDLINE/PubMed
spelling pubmed-44780012015-07-01 IgG4-Associated Cholangitis Can Mimic Hilar Cholangiocarcinoma Zaydfudim, Victor M. Wang, Andrew Y. de Lange, Eduard E. Zhao, Zimin Moskaluk, Christopher A. Bauer, Todd W. Adams, Reid B. Gut Liver Case Report IgG4-associated cholangitis can mimic hilar cholangiocarcinoma. Previously reported patients with IgG4-associated cholangitis mimicking cholangiocarcinoma had elevated serum IgG4 levels and long-segment biliary strictures. However, in the absence of other diagnostic criteria for malignancy, IgG4-associated cholangitis should remain a consideration among patients with normal serum IgG4 and a hilar mass suspicious for cholangiocarcinoma. The presence of a hilar mass and a malignant-appearing biliary stricture in two patients with normal serum IgG4 prompted further evaluation and subsequent concomitant liver and bile duct resection and reconstruction. The diagnosis of IgG4-associated cholangitis was established during the pathologic evaluation of the resected specimens. IgG4-associated cholangitis is a known imitator of hilar cholangiocarcinoma and should be considered in the differential diagnosis even among serologically IgG4-negative patients with a hilar mass prior to operative resection. Gut and Liver 2015-07 2015-06-04 /pmc/articles/PMC4478001/ /pubmed/26033685 http://dx.doi.org/10.5009/gnl14241 Text en Copyright © 2015 by The Korean Society of Gastroenterology, the Korean Society of Gastrointestinal Endoscopy, the Korean Society of Neurogastroenterology and Motility, Korean College of Helicobacter and Upper Gastrointestinal Research, Korean Association for the Study of Intestinal Diseases, the Korean Association for the Study of the Liver, Korean Pancreatobiliary Association, and Korean Society of Gastrointestinal Cancer. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Zaydfudim, Victor M.
Wang, Andrew Y.
de Lange, Eduard E.
Zhao, Zimin
Moskaluk, Christopher A.
Bauer, Todd W.
Adams, Reid B.
IgG4-Associated Cholangitis Can Mimic Hilar Cholangiocarcinoma
title IgG4-Associated Cholangitis Can Mimic Hilar Cholangiocarcinoma
title_full IgG4-Associated Cholangitis Can Mimic Hilar Cholangiocarcinoma
title_fullStr IgG4-Associated Cholangitis Can Mimic Hilar Cholangiocarcinoma
title_full_unstemmed IgG4-Associated Cholangitis Can Mimic Hilar Cholangiocarcinoma
title_short IgG4-Associated Cholangitis Can Mimic Hilar Cholangiocarcinoma
title_sort igg4-associated cholangitis can mimic hilar cholangiocarcinoma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4478001/
https://www.ncbi.nlm.nih.gov/pubmed/26033685
http://dx.doi.org/10.5009/gnl14241
work_keys_str_mv AT zaydfudimvictorm igg4associatedcholangitiscanmimichilarcholangiocarcinoma
AT wangandrewy igg4associatedcholangitiscanmimichilarcholangiocarcinoma
AT delangeeduarde igg4associatedcholangitiscanmimichilarcholangiocarcinoma
AT zhaozimin igg4associatedcholangitiscanmimichilarcholangiocarcinoma
AT moskalukchristophera igg4associatedcholangitiscanmimichilarcholangiocarcinoma
AT bauertoddw igg4associatedcholangitiscanmimichilarcholangiocarcinoma
AT adamsreidb igg4associatedcholangitiscanmimichilarcholangiocarcinoma