IGFBP-5 Promotes Fibrosis Independently of Its Translocation to the Nucleus and Its Interaction with Nucleolin and IGF

BACKGROUND: Insulin-like growth factor binding protein (IGFBP)-5 levels are increased in systemic sclerosis (SSc) skin and lung. We previously reported that IGFBP-5 is a pro-fibrotic factor that induces extracellular matrix (ECM) production and deposition. Since IGFBP-5 contains a nuclear localizati...

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Detalles Bibliográficos
Autores principales: Su, Yunyun, Nishimoto, Tetsuya, Feghali-Bostwick, Carol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4478026/
https://www.ncbi.nlm.nih.gov/pubmed/26103640
http://dx.doi.org/10.1371/journal.pone.0130546

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4478026/
https://www.ncbi.nlm.nih.gov/pubmed/26103640
http://dx.doi.org/10.1371/journal.pone.0130546

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