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Sedation with etomidate-fentanyl versus propofol-fentanyl in colonoscopies: A prospective randomized study

BACKGROUND: The combination of propofol-fentanyl for sedation during colonoscopy is characterized by high prevalence of side effects. Etomidate-fentanyl provides fewer hemodynamic and respiratory complications. The aim of our study was to compare the safety and efficacy of propofol-fentanyl and etom...

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Autores principales: Banihashem, Nadia, Alijanpour, Ebrahim, Basirat, Majid, Shokri Shirvany, Javad, Kashifard, Mehrdad, Taheri, Hasan, Savadkohi, Shahriyar, Hosseini, Vahid, Solimanian, Seyed Sedigheh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Babol University of Medical Sciences 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4478113/
https://www.ncbi.nlm.nih.gov/pubmed/26221491
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author Banihashem, Nadia
Alijanpour, Ebrahim
Basirat, Majid
Shokri Shirvany, Javad
Kashifard, Mehrdad
Taheri, Hasan
Savadkohi, Shahriyar
Hosseini, Vahid
Solimanian, Seyed Sedigheh
author_facet Banihashem, Nadia
Alijanpour, Ebrahim
Basirat, Majid
Shokri Shirvany, Javad
Kashifard, Mehrdad
Taheri, Hasan
Savadkohi, Shahriyar
Hosseini, Vahid
Solimanian, Seyed Sedigheh
author_sort Banihashem, Nadia
collection PubMed
description BACKGROUND: The combination of propofol-fentanyl for sedation during colonoscopy is characterized by high prevalence of side effects. Etomidate-fentanyl provides fewer hemodynamic and respiratory complications. The aim of our study was to compare the safety and efficacy of propofol-fentanyl and etomidate-fentanyl for conscious sedation in elective colonoscopy. METHODS: This double-blind clinical trial was conducted on 90 patients aged between 18- 55 years old who were candidates for elective colonoscopy. Patients were randomized to receive sedation with fentanyl plus propofol or etomidate. Two minutes after injecting 1 micro/kg of fentanyl, the patients received 0.5mg/kg propofol by infusion (25 µ/kg/min) or 0.1 mg/kg etmoidate (15 µ/kg/min). Pulse rate, mean arterial blood pressure, respiratory rate, and saturation of peripheral oxygen (SPO(2)) were monitored. In addition, the patient and colonoscopist satisfaction, the recovery time, sedation and pain score in both groups were assessed. RESULTS: Sedation score in propofol group was higher. Pain score as well as the physician and patient satisfaction showed no significant difference between the two study groups. Hemodynamic changes and arterial saturation were the same in both groups. The duration of recovery was 1.27±0.82 minutes in the etomidate group; versus 2.57±2.46 minutes in the propofol group (P=0.001). Recovery time in the etmoid group was 2.68±3.14 minutes and in the propofol group was 5.53±4.67 minutes (p=0.001). CONCLUSION: The combination of fentanyl and etomidate provides an acceptable alternative to sedation with fentanyl and propofol with the advantage of significantly faster recovery time, in the outpatient setting.
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spelling pubmed-44781132015-07-28 Sedation with etomidate-fentanyl versus propofol-fentanyl in colonoscopies: A prospective randomized study Banihashem, Nadia Alijanpour, Ebrahim Basirat, Majid Shokri Shirvany, Javad Kashifard, Mehrdad Taheri, Hasan Savadkohi, Shahriyar Hosseini, Vahid Solimanian, Seyed Sedigheh Caspian J Intern Med Original Article BACKGROUND: The combination of propofol-fentanyl for sedation during colonoscopy is characterized by high prevalence of side effects. Etomidate-fentanyl provides fewer hemodynamic and respiratory complications. The aim of our study was to compare the safety and efficacy of propofol-fentanyl and etomidate-fentanyl for conscious sedation in elective colonoscopy. METHODS: This double-blind clinical trial was conducted on 90 patients aged between 18- 55 years old who were candidates for elective colonoscopy. Patients were randomized to receive sedation with fentanyl plus propofol or etomidate. Two minutes after injecting 1 micro/kg of fentanyl, the patients received 0.5mg/kg propofol by infusion (25 µ/kg/min) or 0.1 mg/kg etmoidate (15 µ/kg/min). Pulse rate, mean arterial blood pressure, respiratory rate, and saturation of peripheral oxygen (SPO(2)) were monitored. In addition, the patient and colonoscopist satisfaction, the recovery time, sedation and pain score in both groups were assessed. RESULTS: Sedation score in propofol group was higher. Pain score as well as the physician and patient satisfaction showed no significant difference between the two study groups. Hemodynamic changes and arterial saturation were the same in both groups. The duration of recovery was 1.27±0.82 minutes in the etomidate group; versus 2.57±2.46 minutes in the propofol group (P=0.001). Recovery time in the etmoid group was 2.68±3.14 minutes and in the propofol group was 5.53±4.67 minutes (p=0.001). CONCLUSION: The combination of fentanyl and etomidate provides an acceptable alternative to sedation with fentanyl and propofol with the advantage of significantly faster recovery time, in the outpatient setting. Babol University of Medical Sciences 2015 /pmc/articles/PMC4478113/ /pubmed/26221491 Text en © 2015: Caspian Journal of Internal Medicine This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Banihashem, Nadia
Alijanpour, Ebrahim
Basirat, Majid
Shokri Shirvany, Javad
Kashifard, Mehrdad
Taheri, Hasan
Savadkohi, Shahriyar
Hosseini, Vahid
Solimanian, Seyed Sedigheh
Sedation with etomidate-fentanyl versus propofol-fentanyl in colonoscopies: A prospective randomized study
title Sedation with etomidate-fentanyl versus propofol-fentanyl in colonoscopies: A prospective randomized study
title_full Sedation with etomidate-fentanyl versus propofol-fentanyl in colonoscopies: A prospective randomized study
title_fullStr Sedation with etomidate-fentanyl versus propofol-fentanyl in colonoscopies: A prospective randomized study
title_full_unstemmed Sedation with etomidate-fentanyl versus propofol-fentanyl in colonoscopies: A prospective randomized study
title_short Sedation with etomidate-fentanyl versus propofol-fentanyl in colonoscopies: A prospective randomized study
title_sort sedation with etomidate-fentanyl versus propofol-fentanyl in colonoscopies: a prospective randomized study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4478113/
https://www.ncbi.nlm.nih.gov/pubmed/26221491
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