Cargando…

Wells’ Syndrome Mimicking Facial Cellulitis: A Report of Two Cases

Wells’ syndrome (WS), or eosinophilic cellulitis, is an uncommon inflammatory dermatosis of unknown etiology that typically presents with pruritic cellulitis-like plaques on the extremities. Therefore, WS is often misdiagnosed as bacterial cellulitis due to its similarity in presentation. Here, we r...

Descripción completa

Detalles Bibliográficos
Autores principales: Cormerais, Maxence, Poizeau, Florence, Darrieux, Laure, Tisseau, Laurent, Safa, Gilles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4478307/
https://www.ncbi.nlm.nih.gov/pubmed/26120307
http://dx.doi.org/10.1159/000432392
_version_ 1782377864305311744
author Cormerais, Maxence
Poizeau, Florence
Darrieux, Laure
Tisseau, Laurent
Safa, Gilles
author_facet Cormerais, Maxence
Poizeau, Florence
Darrieux, Laure
Tisseau, Laurent
Safa, Gilles
author_sort Cormerais, Maxence
collection PubMed
description Wells’ syndrome (WS), or eosinophilic cellulitis, is an uncommon inflammatory dermatosis of unknown etiology that typically presents with pruritic cellulitis-like plaques on the extremities. Therefore, WS is often misdiagnosed as bacterial cellulitis due to its similarity in presentation. Here, we report two cases of WS that masqueraded as bacterial facial cellulitis. Under treatment with oral prednisone and/or a combination therapy with levocetirizine and hydroxyzine, both patients showed a dramatic improvement of the skin lesions. These cases highlight the need for clinicians to consider WS in the differential diagnosis when evaluating a patient with facial cellulitis that does not respond to an initial antimicrobial regimen. In addition, our cases suggest that combination therapy with levocetirizine and hydroxyzine may be successfully used as corticosteroid-sparing treatment or to prevent relapse after the discontinuation of corticosteroid treatment.
format Online
Article
Text
id pubmed-4478307
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher S. Karger AG
record_format MEDLINE/PubMed
spelling pubmed-44783072015-06-26 Wells’ Syndrome Mimicking Facial Cellulitis: A Report of Two Cases Cormerais, Maxence Poizeau, Florence Darrieux, Laure Tisseau, Laurent Safa, Gilles Case Rep Dermatol Published online: June, 2015 Wells’ syndrome (WS), or eosinophilic cellulitis, is an uncommon inflammatory dermatosis of unknown etiology that typically presents with pruritic cellulitis-like plaques on the extremities. Therefore, WS is often misdiagnosed as bacterial cellulitis due to its similarity in presentation. Here, we report two cases of WS that masqueraded as bacterial facial cellulitis. Under treatment with oral prednisone and/or a combination therapy with levocetirizine and hydroxyzine, both patients showed a dramatic improvement of the skin lesions. These cases highlight the need for clinicians to consider WS in the differential diagnosis when evaluating a patient with facial cellulitis that does not respond to an initial antimicrobial regimen. In addition, our cases suggest that combination therapy with levocetirizine and hydroxyzine may be successfully used as corticosteroid-sparing treatment or to prevent relapse after the discontinuation of corticosteroid treatment. S. Karger AG 2015-06-09 /pmc/articles/PMC4478307/ /pubmed/26120307 http://dx.doi.org/10.1159/000432392 Text en Copyright © 2015 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable to the online version of the article only. Distribution permitted for non-commercial purposes only.
spellingShingle Published online: June, 2015
Cormerais, Maxence
Poizeau, Florence
Darrieux, Laure
Tisseau, Laurent
Safa, Gilles
Wells’ Syndrome Mimicking Facial Cellulitis: A Report of Two Cases
title Wells’ Syndrome Mimicking Facial Cellulitis: A Report of Two Cases
title_full Wells’ Syndrome Mimicking Facial Cellulitis: A Report of Two Cases
title_fullStr Wells’ Syndrome Mimicking Facial Cellulitis: A Report of Two Cases
title_full_unstemmed Wells’ Syndrome Mimicking Facial Cellulitis: A Report of Two Cases
title_short Wells’ Syndrome Mimicking Facial Cellulitis: A Report of Two Cases
title_sort wells’ syndrome mimicking facial cellulitis: a report of two cases
topic Published online: June, 2015
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4478307/
https://www.ncbi.nlm.nih.gov/pubmed/26120307
http://dx.doi.org/10.1159/000432392
work_keys_str_mv AT cormeraismaxence wellssyndromemimickingfacialcellulitisareportoftwocases
AT poizeauflorence wellssyndromemimickingfacialcellulitisareportoftwocases
AT darrieuxlaure wellssyndromemimickingfacialcellulitisareportoftwocases
AT tisseaulaurent wellssyndromemimickingfacialcellulitisareportoftwocases
AT safagilles wellssyndromemimickingfacialcellulitisareportoftwocases