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Rare Neurological Manifestation of Celiac Disease
Celiac disease (CD) is an immune-mediated disease characterized by permanent gastrointestinal tract sensitivity to gluten in genetically predisposed individuals. It has varied clinical manifestations, ranging from gastrointestinal to extraintestinal, including neurological, skin, reproductive and ps...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
S. Karger AG
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4478317/ https://www.ncbi.nlm.nih.gov/pubmed/26120302 http://dx.doi.org/10.1159/000431170 |
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author | Rani, Uzma Imdad, Aamer Beg, Mirza |
author_facet | Rani, Uzma Imdad, Aamer Beg, Mirza |
author_sort | Rani, Uzma |
collection | PubMed |
description | Celiac disease (CD) is an immune-mediated disease characterized by permanent gastrointestinal tract sensitivity to gluten in genetically predisposed individuals. It has varied clinical manifestations, ranging from gastrointestinal to extraintestinal, including neurological, skin, reproductive and psychiatric symptoms, which makes its diagnosis difficult and challenging. Known neurological manifestations of CD include epilepsy with or without occipital calcification, attention deficit hyperactivity disorder and ataxia, headache, neuropathies and behavior disorders. We present the case of a 14-year-old female with headaches and blurred vision for 1 year; she was noted to have papilledema on ophthalmic examination with increased cerebrospinal fluid opening pressure on lumber puncture and was diagnosed as a case of pseudotumor cerebri (PTC). Meanwhile her workup for chronic constipation revealed elevated tissue transglutaminase IgA and antiendomysial IgA antibodies. Upper gastrointestinal endoscopy with duodenal biopsy confirmed the diagnosis of CD. The patient was started on a gluten-free diet, leading to resolution of not only gastrointestinal symptoms but also to almost complete resolution of symptoms of PTC. This report describes the correlation of CD and PTC as its neurological manifestation. |
format | Online Article Text |
id | pubmed-4478317 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | S. Karger AG |
record_format | MEDLINE/PubMed |
spelling | pubmed-44783172015-06-26 Rare Neurological Manifestation of Celiac Disease Rani, Uzma Imdad, Aamer Beg, Mirza Case Rep Gastroenterol Published online: June, 2015 Celiac disease (CD) is an immune-mediated disease characterized by permanent gastrointestinal tract sensitivity to gluten in genetically predisposed individuals. It has varied clinical manifestations, ranging from gastrointestinal to extraintestinal, including neurological, skin, reproductive and psychiatric symptoms, which makes its diagnosis difficult and challenging. Known neurological manifestations of CD include epilepsy with or without occipital calcification, attention deficit hyperactivity disorder and ataxia, headache, neuropathies and behavior disorders. We present the case of a 14-year-old female with headaches and blurred vision for 1 year; she was noted to have papilledema on ophthalmic examination with increased cerebrospinal fluid opening pressure on lumber puncture and was diagnosed as a case of pseudotumor cerebri (PTC). Meanwhile her workup for chronic constipation revealed elevated tissue transglutaminase IgA and antiendomysial IgA antibodies. Upper gastrointestinal endoscopy with duodenal biopsy confirmed the diagnosis of CD. The patient was started on a gluten-free diet, leading to resolution of not only gastrointestinal symptoms but also to almost complete resolution of symptoms of PTC. This report describes the correlation of CD and PTC as its neurological manifestation. S. Karger AG 2015-06-09 /pmc/articles/PMC4478317/ /pubmed/26120302 http://dx.doi.org/10.1159/000431170 Text en Copyright © 2015 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable to the online version of the article only. Distribution permitted for non-commercial purposes only. |
spellingShingle | Published online: June, 2015 Rani, Uzma Imdad, Aamer Beg, Mirza Rare Neurological Manifestation of Celiac Disease |
title | Rare Neurological Manifestation of Celiac Disease |
title_full | Rare Neurological Manifestation of Celiac Disease |
title_fullStr | Rare Neurological Manifestation of Celiac Disease |
title_full_unstemmed | Rare Neurological Manifestation of Celiac Disease |
title_short | Rare Neurological Manifestation of Celiac Disease |
title_sort | rare neurological manifestation of celiac disease |
topic | Published online: June, 2015 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4478317/ https://www.ncbi.nlm.nih.gov/pubmed/26120302 http://dx.doi.org/10.1159/000431170 |
work_keys_str_mv | AT raniuzma rareneurologicalmanifestationofceliacdisease AT imdadaamer rareneurologicalmanifestationofceliacdisease AT begmirza rareneurologicalmanifestationofceliacdisease |