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Rare Neurological Manifestation of Celiac Disease

Celiac disease (CD) is an immune-mediated disease characterized by permanent gastrointestinal tract sensitivity to gluten in genetically predisposed individuals. It has varied clinical manifestations, ranging from gastrointestinal to extraintestinal, including neurological, skin, reproductive and ps...

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Autores principales: Rani, Uzma, Imdad, Aamer, Beg, Mirza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4478317/
https://www.ncbi.nlm.nih.gov/pubmed/26120302
http://dx.doi.org/10.1159/000431170
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author Rani, Uzma
Imdad, Aamer
Beg, Mirza
author_facet Rani, Uzma
Imdad, Aamer
Beg, Mirza
author_sort Rani, Uzma
collection PubMed
description Celiac disease (CD) is an immune-mediated disease characterized by permanent gastrointestinal tract sensitivity to gluten in genetically predisposed individuals. It has varied clinical manifestations, ranging from gastrointestinal to extraintestinal, including neurological, skin, reproductive and psychiatric symptoms, which makes its diagnosis difficult and challenging. Known neurological manifestations of CD include epilepsy with or without occipital calcification, attention deficit hyperactivity disorder and ataxia, headache, neuropathies and behavior disorders. We present the case of a 14-year-old female with headaches and blurred vision for 1 year; she was noted to have papilledema on ophthalmic examination with increased cerebrospinal fluid opening pressure on lumber puncture and was diagnosed as a case of pseudotumor cerebri (PTC). Meanwhile her workup for chronic constipation revealed elevated tissue transglutaminase IgA and antiendomysial IgA antibodies. Upper gastrointestinal endoscopy with duodenal biopsy confirmed the diagnosis of CD. The patient was started on a gluten-free diet, leading to resolution of not only gastrointestinal symptoms but also to almost complete resolution of symptoms of PTC. This report describes the correlation of CD and PTC as its neurological manifestation.
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spelling pubmed-44783172015-06-26 Rare Neurological Manifestation of Celiac Disease Rani, Uzma Imdad, Aamer Beg, Mirza Case Rep Gastroenterol Published online: June, 2015 Celiac disease (CD) is an immune-mediated disease characterized by permanent gastrointestinal tract sensitivity to gluten in genetically predisposed individuals. It has varied clinical manifestations, ranging from gastrointestinal to extraintestinal, including neurological, skin, reproductive and psychiatric symptoms, which makes its diagnosis difficult and challenging. Known neurological manifestations of CD include epilepsy with or without occipital calcification, attention deficit hyperactivity disorder and ataxia, headache, neuropathies and behavior disorders. We present the case of a 14-year-old female with headaches and blurred vision for 1 year; she was noted to have papilledema on ophthalmic examination with increased cerebrospinal fluid opening pressure on lumber puncture and was diagnosed as a case of pseudotumor cerebri (PTC). Meanwhile her workup for chronic constipation revealed elevated tissue transglutaminase IgA and antiendomysial IgA antibodies. Upper gastrointestinal endoscopy with duodenal biopsy confirmed the diagnosis of CD. The patient was started on a gluten-free diet, leading to resolution of not only gastrointestinal symptoms but also to almost complete resolution of symptoms of PTC. This report describes the correlation of CD and PTC as its neurological manifestation. S. Karger AG 2015-06-09 /pmc/articles/PMC4478317/ /pubmed/26120302 http://dx.doi.org/10.1159/000431170 Text en Copyright © 2015 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable to the online version of the article only. Distribution permitted for non-commercial purposes only.
spellingShingle Published online: June, 2015
Rani, Uzma
Imdad, Aamer
Beg, Mirza
Rare Neurological Manifestation of Celiac Disease
title Rare Neurological Manifestation of Celiac Disease
title_full Rare Neurological Manifestation of Celiac Disease
title_fullStr Rare Neurological Manifestation of Celiac Disease
title_full_unstemmed Rare Neurological Manifestation of Celiac Disease
title_short Rare Neurological Manifestation of Celiac Disease
title_sort rare neurological manifestation of celiac disease
topic Published online: June, 2015
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4478317/
https://www.ncbi.nlm.nih.gov/pubmed/26120302
http://dx.doi.org/10.1159/000431170
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