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Alpha-Lipoic Acid and Antioxidant Diet Help to Improve Endothelial Dysfunction in Adolescents with Type 1 Diabetes: A Pilot Trial

After evaluating the prevalence of early endothelial dysfunction, as measured by means of reactive hyperemia in adolescents with type 1 diabetes, we started a 6-month, double-blind, randomized trial to test the efficacy of an antioxidant diet (± alpha-lipoic acid supplementation) to improve endothel...

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Autores principales: Scaramuzza, Andrea, Giani, Elisa, Redaelli, Francesca, Ungheri, Saverio, Macedoni, Maddalena, Giudici, Valentina, Bosetti, Alessandra, Ferrari, Matteo, Zuccotti, Gian Vincenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4478382/
https://www.ncbi.nlm.nih.gov/pubmed/26171398
http://dx.doi.org/10.1155/2015/474561
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author Scaramuzza, Andrea
Giani, Elisa
Redaelli, Francesca
Ungheri, Saverio
Macedoni, Maddalena
Giudici, Valentina
Bosetti, Alessandra
Ferrari, Matteo
Zuccotti, Gian Vincenzo
author_facet Scaramuzza, Andrea
Giani, Elisa
Redaelli, Francesca
Ungheri, Saverio
Macedoni, Maddalena
Giudici, Valentina
Bosetti, Alessandra
Ferrari, Matteo
Zuccotti, Gian Vincenzo
author_sort Scaramuzza, Andrea
collection PubMed
description After evaluating the prevalence of early endothelial dysfunction, as measured by means of reactive hyperemia in adolescents with type 1 diabetes, we started a 6-month, double-blind, randomized trial to test the efficacy of an antioxidant diet (± alpha-lipoic acid supplementation) to improve endothelial dysfunction. Seventy-one children and adolescents, ages 17 ± 3.9 yrs, with type 1 diabetes since 9.5 ± 5.3 yrs, using intensified insulin therapy, were randomized into 3 arms: (a) antioxidant diet 10.000 ORAC + alpha-lipoic acid; (b) antioxidant diet 10.000 ORAC + placebo; (c) controls. BMI, blood pressure, fasting lipid profile, HbA1c, insulin requirement, dietary habits, and body composition were determined in each patient. An antioxidant diet significantly improved endothelial dysfunction when supplemented with alpha-lipoic acid, unlike diet with placebo or controls. A significant reduction in bolus insulin was also observed. We speculate that alpha-lipoic acid might have an antioxidant effect in pediatric diabetes patients by reducing insulin.
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spelling pubmed-44783822015-07-13 Alpha-Lipoic Acid and Antioxidant Diet Help to Improve Endothelial Dysfunction in Adolescents with Type 1 Diabetes: A Pilot Trial Scaramuzza, Andrea Giani, Elisa Redaelli, Francesca Ungheri, Saverio Macedoni, Maddalena Giudici, Valentina Bosetti, Alessandra Ferrari, Matteo Zuccotti, Gian Vincenzo J Diabetes Res Research Article After evaluating the prevalence of early endothelial dysfunction, as measured by means of reactive hyperemia in adolescents with type 1 diabetes, we started a 6-month, double-blind, randomized trial to test the efficacy of an antioxidant diet (± alpha-lipoic acid supplementation) to improve endothelial dysfunction. Seventy-one children and adolescents, ages 17 ± 3.9 yrs, with type 1 diabetes since 9.5 ± 5.3 yrs, using intensified insulin therapy, were randomized into 3 arms: (a) antioxidant diet 10.000 ORAC + alpha-lipoic acid; (b) antioxidant diet 10.000 ORAC + placebo; (c) controls. BMI, blood pressure, fasting lipid profile, HbA1c, insulin requirement, dietary habits, and body composition were determined in each patient. An antioxidant diet significantly improved endothelial dysfunction when supplemented with alpha-lipoic acid, unlike diet with placebo or controls. A significant reduction in bolus insulin was also observed. We speculate that alpha-lipoic acid might have an antioxidant effect in pediatric diabetes patients by reducing insulin. Hindawi Publishing Corporation 2015 2015-06-16 /pmc/articles/PMC4478382/ /pubmed/26171398 http://dx.doi.org/10.1155/2015/474561 Text en Copyright © 2015 Andrea Scaramuzza et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Scaramuzza, Andrea
Giani, Elisa
Redaelli, Francesca
Ungheri, Saverio
Macedoni, Maddalena
Giudici, Valentina
Bosetti, Alessandra
Ferrari, Matteo
Zuccotti, Gian Vincenzo
Alpha-Lipoic Acid and Antioxidant Diet Help to Improve Endothelial Dysfunction in Adolescents with Type 1 Diabetes: A Pilot Trial
title Alpha-Lipoic Acid and Antioxidant Diet Help to Improve Endothelial Dysfunction in Adolescents with Type 1 Diabetes: A Pilot Trial
title_full Alpha-Lipoic Acid and Antioxidant Diet Help to Improve Endothelial Dysfunction in Adolescents with Type 1 Diabetes: A Pilot Trial
title_fullStr Alpha-Lipoic Acid and Antioxidant Diet Help to Improve Endothelial Dysfunction in Adolescents with Type 1 Diabetes: A Pilot Trial
title_full_unstemmed Alpha-Lipoic Acid and Antioxidant Diet Help to Improve Endothelial Dysfunction in Adolescents with Type 1 Diabetes: A Pilot Trial
title_short Alpha-Lipoic Acid and Antioxidant Diet Help to Improve Endothelial Dysfunction in Adolescents with Type 1 Diabetes: A Pilot Trial
title_sort alpha-lipoic acid and antioxidant diet help to improve endothelial dysfunction in adolescents with type 1 diabetes: a pilot trial
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4478382/
https://www.ncbi.nlm.nih.gov/pubmed/26171398
http://dx.doi.org/10.1155/2015/474561
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