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CNS active O-linked glycopeptides

Naturally occurring glycopeptides and glycoproteins play important roles in biological processes. Glycosylation is one of the most common post-translational modifications in vivo. Glycopeptides are involved in cell signaling and sorting, providing cell surface markers for recognition. From the drug...

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Detalles Bibliográficos
Autores principales: Jones, Evan M., Polt, Robin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4478441/
https://www.ncbi.nlm.nih.gov/pubmed/26157795
http://dx.doi.org/10.3389/fchem.2015.00040
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author Jones, Evan M.
Polt, Robin
author_facet Jones, Evan M.
Polt, Robin
author_sort Jones, Evan M.
collection PubMed
description Naturally occurring glycopeptides and glycoproteins play important roles in biological processes. Glycosylation is one of the most common post-translational modifications in vivo. Glycopeptides are involved in cell signaling and sorting, providing cell surface markers for recognition. From the drug design and synthesis perspective, modification of a peptide through glycosylation results in increased bioavailability and bioactivity of glycopeptides in living systems with negligible toxicity of degradation products. Glycopeptide synthesis can be accomplished through incorporation of a glycosylated amino acid in solid phase peptide synthesis (SPPS) to form the desired peptide, or via incorporation of sugar-amino acid moieties. Additionally, research indicates that glycosylation increases penetration of the blood-brain barrier (BBB) by peptides, which may lead to novel therapeutics for neurological disorders. Recent applications of glycopeptides have focused on the in vivo central nervous system (CNS) effects after peripheral administration of centrally active peptides modified with various carbohydrates.
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spelling pubmed-44784412015-07-08 CNS active O-linked glycopeptides Jones, Evan M. Polt, Robin Front Chem Chemistry Naturally occurring glycopeptides and glycoproteins play important roles in biological processes. Glycosylation is one of the most common post-translational modifications in vivo. Glycopeptides are involved in cell signaling and sorting, providing cell surface markers for recognition. From the drug design and synthesis perspective, modification of a peptide through glycosylation results in increased bioavailability and bioactivity of glycopeptides in living systems with negligible toxicity of degradation products. Glycopeptide synthesis can be accomplished through incorporation of a glycosylated amino acid in solid phase peptide synthesis (SPPS) to form the desired peptide, or via incorporation of sugar-amino acid moieties. Additionally, research indicates that glycosylation increases penetration of the blood-brain barrier (BBB) by peptides, which may lead to novel therapeutics for neurological disorders. Recent applications of glycopeptides have focused on the in vivo central nervous system (CNS) effects after peripheral administration of centrally active peptides modified with various carbohydrates. Frontiers Media S.A. 2015-06-24 /pmc/articles/PMC4478441/ /pubmed/26157795 http://dx.doi.org/10.3389/fchem.2015.00040 Text en Copyright © 2015 Jones and Polt. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Jones, Evan M.
Polt, Robin
CNS active O-linked glycopeptides
title CNS active O-linked glycopeptides
title_full CNS active O-linked glycopeptides
title_fullStr CNS active O-linked glycopeptides
title_full_unstemmed CNS active O-linked glycopeptides
title_short CNS active O-linked glycopeptides
title_sort cns active o-linked glycopeptides
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4478441/
https://www.ncbi.nlm.nih.gov/pubmed/26157795
http://dx.doi.org/10.3389/fchem.2015.00040
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