Evidence that synthetic lethality underlies the mutual exclusivity of oncogenic KRAS and EGFR mutations in lung adenocarcinoma

Human lung adenocarcinomas (LUAD) contain mutations in EGFR in ∼15% of cases and in KRAS in ∼30%, yet no individual adenocarcinoma appears to carry activating mutations in both genes, a finding we have confirmed by re-analysis of data from over 600 LUAD. Here we provide evidence that co-occurrence o...

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Detalles Bibliográficos
Autores principales: Unni, Arun M, Lockwood, William W, Zejnullahu, Kreshnik, Lee-Lin, Shih-Queen, Varmus, Harold
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Human Biology and Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4478584/
https://www.ncbi.nlm.nih.gov/pubmed/26047463
http://dx.doi.org/10.7554/eLife.06907

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