Genome-wide association analysis identifies three new risk loci for gout arthritis in Han Chinese

Gout is one of the most common types of inflammatory arthritis, caused by the deposition of monosodium urate crystals in and around the joints. Previous genome-wide association studies (GWASs) have identified many genetic loci associated with raised serum urate concentrations. However, hyperuricemia...

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Detalles Bibliográficos
Autores principales: Li, Changgui, Li, Zhiqiang, Liu, Shiguo, Wang, Can, Han, Lin, Cui, Lingling, Zhou, Jingguo, Zou, Hejian, Liu, Zhen, Chen, Jianhua, Cheng, Xiaoyu, Zhou, Zhaowei, Ding, Chengcheng, Wang, Meng, Chen, Tong, Cui, Ying, He, Hongmei, Zhang, Keke, Yin, Congcong, Wang, Yunlong, Xing, Shichao, Li, Baojie, Ji, Jue, Jia, Zhaotong, Ma, Lidan, Niu, Jiapeng, Xin, Ying, Liu, Tian, Chu, Nan, Yu, Qing, Ren, Wei, Wang, Xuefeng, Zhang, Aiqing, Sun, Yuping, Wang, Haili, Lu, Jie, Li, Yuanyuan, Qing, Yufeng, Chen, Gang, Wang, Yangang, Zhou, Li, Niu, Haitao, Liang, Jun, Dong, Qian, Li, Xinde, Mi, Qing-Sheng, Shi, Yongyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479022/
https://www.ncbi.nlm.nih.gov/pubmed/25967671
http://dx.doi.org/10.1038/ncomms8041
Descripción
Sumario:Gout is one of the most common types of inflammatory arthritis, caused by the deposition of monosodium urate crystals in and around the joints. Previous genome-wide association studies (GWASs) have identified many genetic loci associated with raised serum urate concentrations. However, hyperuricemia alone is not sufficient for the development of gout arthritis. Here we conduct a multistage GWAS in Han Chinese using 4,275 male gout patients and 6,272 normal male controls (1,255 cases and 1,848 controls were genome-wide genotyped), with an additional 1,644 hyperuricemic controls. We discover three new risk loci, 17q23.2 (rs11653176, P=1.36 × 10(−13), BCAS3), 9p24.2 (rs12236871, P=1.48 × 10(−10), RFX3) and 11p15.5 (rs179785, P=1.28 × 10(−8), KCNQ1), which contain inflammatory candidate genes. Our results suggest that these loci are most likely related to the progression from hyperuricemia to inflammatory gout, which will provide new insights into the pathogenesis of gout arthritis.

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