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Genome-wide association analysis identifies three new risk loci for gout arthritis in Han Chinese
Gout is one of the most common types of inflammatory arthritis, caused by the deposition of monosodium urate crystals in and around the joints. Previous genome-wide association studies (GWASs) have identified many genetic loci associated with raised serum urate concentrations. However, hyperuricemia...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Pub. Group
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479022/ https://www.ncbi.nlm.nih.gov/pubmed/25967671 http://dx.doi.org/10.1038/ncomms8041 |
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| author | Li, Changgui Li, Zhiqiang Liu, Shiguo Wang, Can Han, Lin Cui, Lingling Zhou, Jingguo Zou, Hejian Liu, Zhen Chen, Jianhua Cheng, Xiaoyu Zhou, Zhaowei Ding, Chengcheng Wang, Meng Chen, Tong Cui, Ying He, Hongmei Zhang, Keke Yin, Congcong Wang, Yunlong Xing, Shichao Li, Baojie Ji, Jue Jia, Zhaotong Ma, Lidan Niu, Jiapeng Xin, Ying Liu, Tian Chu, Nan Yu, Qing Ren, Wei Wang, Xuefeng Zhang, Aiqing Sun, Yuping Wang, Haili Lu, Jie Li, Yuanyuan Qing, Yufeng Chen, Gang Wang, Yangang Zhou, Li Niu, Haitao Liang, Jun Dong, Qian Li, Xinde Mi, Qing-Sheng Shi, Yongyong |
| author_facet | Li, Changgui Li, Zhiqiang Liu, Shiguo Wang, Can Han, Lin Cui, Lingling Zhou, Jingguo Zou, Hejian Liu, Zhen Chen, Jianhua Cheng, Xiaoyu Zhou, Zhaowei Ding, Chengcheng Wang, Meng Chen, Tong Cui, Ying He, Hongmei Zhang, Keke Yin, Congcong Wang, Yunlong Xing, Shichao Li, Baojie Ji, Jue Jia, Zhaotong Ma, Lidan Niu, Jiapeng Xin, Ying Liu, Tian Chu, Nan Yu, Qing Ren, Wei Wang, Xuefeng Zhang, Aiqing Sun, Yuping Wang, Haili Lu, Jie Li, Yuanyuan Qing, Yufeng Chen, Gang Wang, Yangang Zhou, Li Niu, Haitao Liang, Jun Dong, Qian Li, Xinde Mi, Qing-Sheng Shi, Yongyong |
| author_sort | Li, Changgui |
| collection | PubMed |
| description | Gout is one of the most common types of inflammatory arthritis, caused by the deposition of monosodium urate crystals in and around the joints. Previous genome-wide association studies (GWASs) have identified many genetic loci associated with raised serum urate concentrations. However, hyperuricemia alone is not sufficient for the development of gout arthritis. Here we conduct a multistage GWAS in Han Chinese using 4,275 male gout patients and 6,272 normal male controls (1,255 cases and 1,848 controls were genome-wide genotyped), with an additional 1,644 hyperuricemic controls. We discover three new risk loci, 17q23.2 (rs11653176, P=1.36 × 10(−13), BCAS3), 9p24.2 (rs12236871, P=1.48 × 10(−10), RFX3) and 11p15.5 (rs179785, P=1.28 × 10(−8), KCNQ1), which contain inflammatory candidate genes. Our results suggest that these loci are most likely related to the progression from hyperuricemia to inflammatory gout, which will provide new insights into the pathogenesis of gout arthritis. |
| format | Online Article Text |
| id | pubmed-4479022 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2015 |
| publisher | Nature Pub. Group |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-44790222015-06-29 Genome-wide association analysis identifies three new risk loci for gout arthritis in Han Chinese Li, Changgui Li, Zhiqiang Liu, Shiguo Wang, Can Han, Lin Cui, Lingling Zhou, Jingguo Zou, Hejian Liu, Zhen Chen, Jianhua Cheng, Xiaoyu Zhou, Zhaowei Ding, Chengcheng Wang, Meng Chen, Tong Cui, Ying He, Hongmei Zhang, Keke Yin, Congcong Wang, Yunlong Xing, Shichao Li, Baojie Ji, Jue Jia, Zhaotong Ma, Lidan Niu, Jiapeng Xin, Ying Liu, Tian Chu, Nan Yu, Qing Ren, Wei Wang, Xuefeng Zhang, Aiqing Sun, Yuping Wang, Haili Lu, Jie Li, Yuanyuan Qing, Yufeng Chen, Gang Wang, Yangang Zhou, Li Niu, Haitao Liang, Jun Dong, Qian Li, Xinde Mi, Qing-Sheng Shi, Yongyong Nat Commun Article Gout is one of the most common types of inflammatory arthritis, caused by the deposition of monosodium urate crystals in and around the joints. Previous genome-wide association studies (GWASs) have identified many genetic loci associated with raised serum urate concentrations. However, hyperuricemia alone is not sufficient for the development of gout arthritis. Here we conduct a multistage GWAS in Han Chinese using 4,275 male gout patients and 6,272 normal male controls (1,255 cases and 1,848 controls were genome-wide genotyped), with an additional 1,644 hyperuricemic controls. We discover three new risk loci, 17q23.2 (rs11653176, P=1.36 × 10(−13), BCAS3), 9p24.2 (rs12236871, P=1.48 × 10(−10), RFX3) and 11p15.5 (rs179785, P=1.28 × 10(−8), KCNQ1), which contain inflammatory candidate genes. Our results suggest that these loci are most likely related to the progression from hyperuricemia to inflammatory gout, which will provide new insights into the pathogenesis of gout arthritis. Nature Pub. Group 2015-05-13 /pmc/articles/PMC4479022/ /pubmed/25967671 http://dx.doi.org/10.1038/ncomms8041 Text en Copyright © 2015, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| spellingShingle | Article Li, Changgui Li, Zhiqiang Liu, Shiguo Wang, Can Han, Lin Cui, Lingling Zhou, Jingguo Zou, Hejian Liu, Zhen Chen, Jianhua Cheng, Xiaoyu Zhou, Zhaowei Ding, Chengcheng Wang, Meng Chen, Tong Cui, Ying He, Hongmei Zhang, Keke Yin, Congcong Wang, Yunlong Xing, Shichao Li, Baojie Ji, Jue Jia, Zhaotong Ma, Lidan Niu, Jiapeng Xin, Ying Liu, Tian Chu, Nan Yu, Qing Ren, Wei Wang, Xuefeng Zhang, Aiqing Sun, Yuping Wang, Haili Lu, Jie Li, Yuanyuan Qing, Yufeng Chen, Gang Wang, Yangang Zhou, Li Niu, Haitao Liang, Jun Dong, Qian Li, Xinde Mi, Qing-Sheng Shi, Yongyong Genome-wide association analysis identifies three new risk loci for gout arthritis in Han Chinese |
| title | Genome-wide association analysis identifies three new risk loci for gout arthritis in Han Chinese |
| title_full | Genome-wide association analysis identifies three new risk loci for gout arthritis in Han Chinese |
| title_fullStr | Genome-wide association analysis identifies three new risk loci for gout arthritis in Han Chinese |
| title_full_unstemmed | Genome-wide association analysis identifies three new risk loci for gout arthritis in Han Chinese |
| title_short | Genome-wide association analysis identifies three new risk loci for gout arthritis in Han Chinese |
| title_sort | genome-wide association analysis identifies three new risk loci for gout arthritis in han chinese |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479022/ https://www.ncbi.nlm.nih.gov/pubmed/25967671 http://dx.doi.org/10.1038/ncomms8041 |
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