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BlastXtract2: Improving early exploration of (meta) genomes

To manage and intelligently mine the avalanche of genomic sequences intuitive and user-friendly graphical interfaces are required. Here we present BlastXtract2 which exclusively facilitates early exploration of un-annotated genomic and metagenomic sequences. Various formats of translated searches, i...

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Detalles Bibliográficos
Autores principales: de Weerd, Heleen, van der Veen, Bernd E, Claesson, Marcus J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Biomedical Informatics 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479055/
https://www.ncbi.nlm.nih.gov/pubmed/26124555
http://dx.doi.org/10.6026/97320630011173
Descripción
Sumario:To manage and intelligently mine the avalanche of genomic sequences intuitive and user-friendly graphical interfaces are required. Here we present BlastXtract2 which exclusively facilitates early exploration of un-annotated genomic and metagenomic sequences. Various formats of translated searches, including the commonly used BlastX, of multiple sequences against multiple protein databases can be uploaded to a relational database server, which can be accessed via a locally installed web-server. There, an intuitive GUI allows straightforward data-mining and enables quick detection of potential frameshifts and poorly sequenced or assembled regions, thereby contributing in making BlastXtract2 a unique and valuable tool for early exploration of (meta)genomic sequences. AVAILABILITY: Source code, documentation and an online demo version are available at https://github.com/ ClaessonLab/BlastXtract2