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Differential hepatotoxicity of dietary and DNL-derived palmitate in the methionine-choline-deficient model of steatohepatitis

BACKGROUND: Saturated fatty acids are toxic to liver cells and are believed to play a central role in the pathogenesis of non-alcoholic steatohepatitis. In experimental steatohepatitis induced by feeding mice a methionine-choline-deficient (MCD) diet, the degree of liver damage is related to dietary...

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Detalles Bibliográficos
Autores principales: Pierce, Andrew A., Pickens, Michael K., Siao, Kevin, Grenert, James P., Maher, Jacquelyn J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479079/
https://www.ncbi.nlm.nih.gov/pubmed/26103964
http://dx.doi.org/10.1186/s12876-015-0298-y