Wild type human TDP-43 potentiates ALS-linked mutant TDP-43 driven progressive motor and cortical neuron degeneration with pathological features of ALS

INTRODUCTION: Amyotrophic lateral sclerosis (ALS) is a relentlessly progressive neurodegenerative disorder, and cytoplasmic inclusions containing transactive response (TAR) DNA binding protein (TDP-43) are present in ~90 % of cases. Here we report detailed pathology in human TDP-43 transgenic mice t...

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Detalles Bibliográficos
Autores principales: Mitchell, Jacqueline C, Constable, Remy, So, Eva, Vance, Caroline, Scotter, Emma, Glover, Leanne, Hortobagyi, Tibor, Arnold, Eveline S., Ling, Shuo-Chien, McAlonis, Melissa, Da Cruz, Sandrine, Polymenidou, Magda, Tessarolo, Lino, Cleveland, Don W, Shaw, Christopher E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479086/
https://www.ncbi.nlm.nih.gov/pubmed/26108367
http://dx.doi.org/10.1186/s40478-015-0212-4

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