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Exposure to concentrated ambient particulate matter induces reversible increase of heart weight in spontaneously hypertensive rats

BACKGROUND: Exposure to ambient PM(2.5) increases cardiovascular mortality and morbidity. To delineate the underlying biological mechanism, we investigated the time dependence of cardiovascular response to chronic exposure to concentrated ambient PM(2.5) (CAP). METHODS: Spontaneously hypertensive ra...

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Autores principales: Ying, Zhekang, Xie, Xiaoyun, Bai, Yuntao, Chen, Minjie, Wang, Xiaoke, Zhang, Xuan, Morishita, Masako, Sun, Qinghua, Rajagopalan, Sanjay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479240/
https://www.ncbi.nlm.nih.gov/pubmed/26108756
http://dx.doi.org/10.1186/s12989-015-0092-6
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author Ying, Zhekang
Xie, Xiaoyun
Bai, Yuntao
Chen, Minjie
Wang, Xiaoke
Zhang, Xuan
Morishita, Masako
Sun, Qinghua
Rajagopalan, Sanjay
author_facet Ying, Zhekang
Xie, Xiaoyun
Bai, Yuntao
Chen, Minjie
Wang, Xiaoke
Zhang, Xuan
Morishita, Masako
Sun, Qinghua
Rajagopalan, Sanjay
author_sort Ying, Zhekang
collection PubMed
description BACKGROUND: Exposure to ambient PM(2.5) increases cardiovascular mortality and morbidity. To delineate the underlying biological mechanism, we investigated the time dependence of cardiovascular response to chronic exposure to concentrated ambient PM(2.5) (CAP). METHODS: Spontaneously hypertensive rats (SHR) were exposed to CAP for 15 weeks, and blood pressure (BP), cardiac function and structure, and inflammations of lung, hypothalamus, and heart were measured at different time points. RESULTS: Chronic exposure to CAP significantly increased BP, and withdrawal from CAP exposure restored BP. Consistent with its BP effect, chronic exposure to CAP significantly decreased cardiac stroke volume and output in SHR, accompanied by increased heart weight and increased cardiac expression of hypertrophic markers ACTA1 and MYH7. Withdrawal from CAP exposure restored cardiac function, weight, and expression of hypertrophic markers, supporting the notion that cardiac dysfunction and hypertrophy is subsequent to hypertension. In agreement with the role of systemic inflammation in mediating the cardiovascular effects of CAP exposure, chronic exposure to CAP markedly increased expression of pro-inflammatory cytokines in lung, heart, and hypothalamus. However, withdrawal from exposure resolves inflammation in the heart and hypothalamus, but not in the lung, suggesting that CAP exposure-induced systemic inflammation may be independent of pulmonary inflammation. CONCLUSION: Chronic exposure to CAP induces reversible cardiac dysfunction and hypertrophy, which is likely to be subsequent to the elevation in BP and induction of systemic inflammation as evidenced by increased mRNA expression of pro-inflammatory cytokines in diverse tissues.
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spelling pubmed-44792402015-06-25 Exposure to concentrated ambient particulate matter induces reversible increase of heart weight in spontaneously hypertensive rats Ying, Zhekang Xie, Xiaoyun Bai, Yuntao Chen, Minjie Wang, Xiaoke Zhang, Xuan Morishita, Masako Sun, Qinghua Rajagopalan, Sanjay Part Fibre Toxicol Research BACKGROUND: Exposure to ambient PM(2.5) increases cardiovascular mortality and morbidity. To delineate the underlying biological mechanism, we investigated the time dependence of cardiovascular response to chronic exposure to concentrated ambient PM(2.5) (CAP). METHODS: Spontaneously hypertensive rats (SHR) were exposed to CAP for 15 weeks, and blood pressure (BP), cardiac function and structure, and inflammations of lung, hypothalamus, and heart were measured at different time points. RESULTS: Chronic exposure to CAP significantly increased BP, and withdrawal from CAP exposure restored BP. Consistent with its BP effect, chronic exposure to CAP significantly decreased cardiac stroke volume and output in SHR, accompanied by increased heart weight and increased cardiac expression of hypertrophic markers ACTA1 and MYH7. Withdrawal from CAP exposure restored cardiac function, weight, and expression of hypertrophic markers, supporting the notion that cardiac dysfunction and hypertrophy is subsequent to hypertension. In agreement with the role of systemic inflammation in mediating the cardiovascular effects of CAP exposure, chronic exposure to CAP markedly increased expression of pro-inflammatory cytokines in lung, heart, and hypothalamus. However, withdrawal from exposure resolves inflammation in the heart and hypothalamus, but not in the lung, suggesting that CAP exposure-induced systemic inflammation may be independent of pulmonary inflammation. CONCLUSION: Chronic exposure to CAP induces reversible cardiac dysfunction and hypertrophy, which is likely to be subsequent to the elevation in BP and induction of systemic inflammation as evidenced by increased mRNA expression of pro-inflammatory cytokines in diverse tissues. BioMed Central 2015-06-25 /pmc/articles/PMC4479240/ /pubmed/26108756 http://dx.doi.org/10.1186/s12989-015-0092-6 Text en © Ying et al. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Ying, Zhekang
Xie, Xiaoyun
Bai, Yuntao
Chen, Minjie
Wang, Xiaoke
Zhang, Xuan
Morishita, Masako
Sun, Qinghua
Rajagopalan, Sanjay
Exposure to concentrated ambient particulate matter induces reversible increase of heart weight in spontaneously hypertensive rats
title Exposure to concentrated ambient particulate matter induces reversible increase of heart weight in spontaneously hypertensive rats
title_full Exposure to concentrated ambient particulate matter induces reversible increase of heart weight in spontaneously hypertensive rats
title_fullStr Exposure to concentrated ambient particulate matter induces reversible increase of heart weight in spontaneously hypertensive rats
title_full_unstemmed Exposure to concentrated ambient particulate matter induces reversible increase of heart weight in spontaneously hypertensive rats
title_short Exposure to concentrated ambient particulate matter induces reversible increase of heart weight in spontaneously hypertensive rats
title_sort exposure to concentrated ambient particulate matter induces reversible increase of heart weight in spontaneously hypertensive rats
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479240/
https://www.ncbi.nlm.nih.gov/pubmed/26108756
http://dx.doi.org/10.1186/s12989-015-0092-6
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