South African HIV-1 subtype C transmitted variants with a specific V2 motif show higher dependence on α4β7 for replication

BACKGROUND: The integrin α4β7 mediates the trafficking of immune cells to the gut associated lymphoid tissue (GALT) and is an attachment factor for the HIV gp120 envelope glycoprotein. We developed a viral replication inhibition assay to more clearly evaluate the role of α4β7 in HIV infection and th...

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Detalles Bibliográficos
Autores principales: Richardson, Simone I, Gray, Elin S, Mkhize, Nonhlanhla N, Sheward, Daniel J, Lambson, Bronwen E, Wibmer, Constantinos Kurt, Masson, Lindi, Werner, Lise, Garrett, Nigel, Passmore, Jo-Ann S, Karim, Quarraisha Abdool, Karim, Salim S Abdool, Williamson, Carolyn, Moore, Penny L, Morris, Lynn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479312/
https://www.ncbi.nlm.nih.gov/pubmed/26105197
http://dx.doi.org/10.1186/s12977-015-0183-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479312/
https://www.ncbi.nlm.nih.gov/pubmed/26105197
http://dx.doi.org/10.1186/s12977-015-0183-3

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