Pharmacological targeting of valosin containing protein (VCP) induces DNA damage and selectively kills canine lymphoma cells

BACKGROUND: Valosin containing protein (VCP) is a critical mediator of protein homeostasis and may represent a valuable therapeutic target for several forms of cancer. Overexpression of VCP occurs in many cancers, and often in a manner correlating with malignancy and poor outcome. Here, we analyzed...

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Detalles Bibliográficos
Autores principales: Nadeau, Marie-Ève, Rico, Charlène, Tsoi, Mayra, Vivancos, Mélanie, Filimon, Sabin, Paquet, Marilène, Boerboom, Derek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479320/
https://www.ncbi.nlm.nih.gov/pubmed/26104798
http://dx.doi.org/10.1186/s12885-015-1489-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479320/
https://www.ncbi.nlm.nih.gov/pubmed/26104798
http://dx.doi.org/10.1186/s12885-015-1489-1

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