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Multivariate Analysis of Prognostic Biomarkers in Surgically Treated Endometrial Cancer
OBJECTIVE: The aim of this study was to identify biomarkers with prognostic value in the setting of surgically treated endometrial cancer. METHODS: Medical data for 282 patients with surgically treated endometrial cancer were reviewed retrospectively. Preoperative concentrations of six serum biomark...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479375/ https://www.ncbi.nlm.nih.gov/pubmed/26107255 http://dx.doi.org/10.1371/journal.pone.0130640 |
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author | Li, Jianpei Lin, Jianhua Luo, Yaoling Kuang, Miaohuan Liu, Yijun |
author_facet | Li, Jianpei Lin, Jianhua Luo, Yaoling Kuang, Miaohuan Liu, Yijun |
author_sort | Li, Jianpei |
collection | PubMed |
description | OBJECTIVE: The aim of this study was to identify biomarkers with prognostic value in the setting of surgically treated endometrial cancer. METHODS: Medical data for 282 patients with surgically treated endometrial cancer were reviewed retrospectively. Preoperative concentrations of six serum biomarkers (CA125, CA15-3, C-reactive protein [CRP], D-dimer [D-D], platelet-to-lymphocyte ratio [PLR], and neutrophil-to-lymphocyte ratio [NLR]) were analysed to determine potential associations with clinicopathologic characteristics and to assess prognostic values separately via Kaplan-Meier method and multivariate Cox regression. RESULTS: In univariate analyses, the 5-year overall survival (OS) rate was 86.5% for a maximum follow-up period of 75 months. High concentrations of CA125, CA15-3, CRP, D-D, PLR, and NLR each proved significantly predictive of poor survival (log-rank test, P<0.01). CRP and D-D were identified as independent prognosticators, using a Cox regression model. Study patients were then stratified (based on combined independent risk factors) into three tiers (P<0.001), marked by 5-year OS rates of 92.1%, 78.4%, and 33.3%. CONCLUSIONS: All serum biomarkers assessed (CA125, CA15-3, CRP, D-D, PLR, and NLR) proved to be valid prognostic indices of surgically treated endometrial cancer. A novel prognostic grouping system, incorporating independent risk factors (CRP and D-D Concentrations), may have merit in assessing these patients preoperatively, providing a biologic basis for improved clinical staging. |
format | Online Article Text |
id | pubmed-4479375 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-44793752015-06-29 Multivariate Analysis of Prognostic Biomarkers in Surgically Treated Endometrial Cancer Li, Jianpei Lin, Jianhua Luo, Yaoling Kuang, Miaohuan Liu, Yijun PLoS One Research Article OBJECTIVE: The aim of this study was to identify biomarkers with prognostic value in the setting of surgically treated endometrial cancer. METHODS: Medical data for 282 patients with surgically treated endometrial cancer were reviewed retrospectively. Preoperative concentrations of six serum biomarkers (CA125, CA15-3, C-reactive protein [CRP], D-dimer [D-D], platelet-to-lymphocyte ratio [PLR], and neutrophil-to-lymphocyte ratio [NLR]) were analysed to determine potential associations with clinicopathologic characteristics and to assess prognostic values separately via Kaplan-Meier method and multivariate Cox regression. RESULTS: In univariate analyses, the 5-year overall survival (OS) rate was 86.5% for a maximum follow-up period of 75 months. High concentrations of CA125, CA15-3, CRP, D-D, PLR, and NLR each proved significantly predictive of poor survival (log-rank test, P<0.01). CRP and D-D were identified as independent prognosticators, using a Cox regression model. Study patients were then stratified (based on combined independent risk factors) into three tiers (P<0.001), marked by 5-year OS rates of 92.1%, 78.4%, and 33.3%. CONCLUSIONS: All serum biomarkers assessed (CA125, CA15-3, CRP, D-D, PLR, and NLR) proved to be valid prognostic indices of surgically treated endometrial cancer. A novel prognostic grouping system, incorporating independent risk factors (CRP and D-D Concentrations), may have merit in assessing these patients preoperatively, providing a biologic basis for improved clinical staging. Public Library of Science 2015-06-24 /pmc/articles/PMC4479375/ /pubmed/26107255 http://dx.doi.org/10.1371/journal.pone.0130640 Text en © 2015 Li et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Li, Jianpei Lin, Jianhua Luo, Yaoling Kuang, Miaohuan Liu, Yijun Multivariate Analysis of Prognostic Biomarkers in Surgically Treated Endometrial Cancer |
title | Multivariate Analysis of Prognostic Biomarkers in Surgically Treated Endometrial Cancer |
title_full | Multivariate Analysis of Prognostic Biomarkers in Surgically Treated Endometrial Cancer |
title_fullStr | Multivariate Analysis of Prognostic Biomarkers in Surgically Treated Endometrial Cancer |
title_full_unstemmed | Multivariate Analysis of Prognostic Biomarkers in Surgically Treated Endometrial Cancer |
title_short | Multivariate Analysis of Prognostic Biomarkers in Surgically Treated Endometrial Cancer |
title_sort | multivariate analysis of prognostic biomarkers in surgically treated endometrial cancer |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479375/ https://www.ncbi.nlm.nih.gov/pubmed/26107255 http://dx.doi.org/10.1371/journal.pone.0130640 |
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