A Metabolic Stress-inducible miR-34a-HNF4α Pathway Regulates Lipid and Lipoprotein Metabolism

Non-alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases, but its underlying mechanism is poorly understood. Here we show that hepatocyte nuclear factor 4α (HNF4α), a liver-enriched nuclear hormone receptor, is markedly inhibited whereas miR-34a is highly induced in patient...

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Detalles Bibliográficos
Autores principales: Xu, Yang, Zalzala, Munaf, Xu, Jiesi, Li, Yuanyuan, Yin, Liya, Zhang, Yanqiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479415/
https://www.ncbi.nlm.nih.gov/pubmed/26100857
http://dx.doi.org/10.1038/ncomms8466

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479415/
https://www.ncbi.nlm.nih.gov/pubmed/26100857
http://dx.doi.org/10.1038/ncomms8466

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