PI3K-C2γ is a Rab5 effector selectively controlling endosomal Akt2 activation downstream of insulin signalling

In the liver, insulin-mediated activation of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway is at the core of metabolic control. Multiple PI3K and Akt isoenzymes are found in hepatocytes and whether isoform-selective interplays exist is currently unclear. Here we report that insulin signalling...

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Detalles Bibliográficos
Autores principales: Braccini, Laura, Ciraolo, Elisa, Campa, Carlo C., Perino, Alessia, Longo, Dario L., Tibolla, Gianpaolo, Pregnolato, Marco, Cao, Yanyan, Tassone, Beatrice, Damilano, Federico, Laffargue, Muriel, Calautti, Enzo, Falasca, Marco, Norata, Giuseppe D., Backer, Jonathan M., Hirsch, Emilio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479417/
https://www.ncbi.nlm.nih.gov/pubmed/26100075
http://dx.doi.org/10.1038/ncomms8400

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