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Simulation-Guided DNA Probe Design for Consistently Ultraspecific Hybridization
Hybridization of complementary sequences is one of the central tenets of nucleic acid chemistry; however, the unintended binding of closely related sequences limits the accuracy of hybridization-based approaches for analyzing nucleic acids. Thermodynamics-guided probe design and empirical optimizati...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479422/ https://www.ncbi.nlm.nih.gov/pubmed/26100802 http://dx.doi.org/10.1038/nchem.2266 |