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Rupatadine: efficacy and safety of a non-sedating antihistamine with PAF-antagonist effects
Rupatadine is a modern non-sedating H1-antihistamine that also haswith additional antagonist effects on platelet-activating factor (PAF). Under the tradenames Rupafin® and Urtimed®, Rrupatadine is approvedregistered in Germany for the treatment of allergic rhinitis and urticaria infor adults and chi...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Urban & Vogel
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479428/ https://www.ncbi.nlm.nih.gov/pubmed/26120520 http://dx.doi.org/10.1007/s40629-014-0011-7 |
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author | Shamizadeh, Soja Brockow, Knut Ring, Johannes |
author_facet | Shamizadeh, Soja Brockow, Knut Ring, Johannes |
author_sort | Shamizadeh, Soja |
collection | PubMed |
description | Rupatadine is a modern non-sedating H1-antihistamine that also haswith additional antagonist effects on platelet-activating factor (PAF). Under the tradenames Rupafin® and Urtimed®, Rrupatadine is approvedregistered in Germany for the treatment of allergic rhinitis and urticaria infor adults and children aged over 12 years. In this review, the available literature available to date onregarding the pharmacological profile and clinical application of Rrupatadine is reviewed and compared to other conventional histamines. In conclusionFinally, the side effects, safety and interaction profileincompatibility of Rrupatadine are discussed. Due to CYP p450 metabolism, Rrupatadine should not be given together with Eerythromycin, Kketoconazole or grapefruit juice. Rupatadine has been found to be effective and safe Iin a variety of randomized clinical trials both in both seasonal and perennial allergic rhinitis, as well as inbut also chronic urticaria Rupatadine has been found as effective and safe. |
format | Online Article Text |
id | pubmed-4479428 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Urban & Vogel |
record_format | MEDLINE/PubMed |
spelling | pubmed-44794282015-06-26 Rupatadine: efficacy and safety of a non-sedating antihistamine with PAF-antagonist effects Shamizadeh, Soja Brockow, Knut Ring, Johannes Allergo J Int Review Article Rupatadine is a modern non-sedating H1-antihistamine that also haswith additional antagonist effects on platelet-activating factor (PAF). Under the tradenames Rupafin® and Urtimed®, Rrupatadine is approvedregistered in Germany for the treatment of allergic rhinitis and urticaria infor adults and children aged over 12 years. In this review, the available literature available to date onregarding the pharmacological profile and clinical application of Rrupatadine is reviewed and compared to other conventional histamines. In conclusionFinally, the side effects, safety and interaction profileincompatibility of Rrupatadine are discussed. Due to CYP p450 metabolism, Rrupatadine should not be given together with Eerythromycin, Kketoconazole or grapefruit juice. Rupatadine has been found to be effective and safe Iin a variety of randomized clinical trials both in both seasonal and perennial allergic rhinitis, as well as inbut also chronic urticaria Rupatadine has been found as effective and safe. Urban & Vogel 2014-05-09 2014 /pmc/articles/PMC4479428/ /pubmed/26120520 http://dx.doi.org/10.1007/s40629-014-0011-7 Text en © Urban & Vogel 2014 |
spellingShingle | Review Article Shamizadeh, Soja Brockow, Knut Ring, Johannes Rupatadine: efficacy and safety of a non-sedating antihistamine with PAF-antagonist effects |
title | Rupatadine: efficacy and safety of a non-sedating antihistamine with PAF-antagonist effects |
title_full | Rupatadine: efficacy and safety of a non-sedating antihistamine with PAF-antagonist effects |
title_fullStr | Rupatadine: efficacy and safety of a non-sedating antihistamine with PAF-antagonist effects |
title_full_unstemmed | Rupatadine: efficacy and safety of a non-sedating antihistamine with PAF-antagonist effects |
title_short | Rupatadine: efficacy and safety of a non-sedating antihistamine with PAF-antagonist effects |
title_sort | rupatadine: efficacy and safety of a non-sedating antihistamine with paf-antagonist effects |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479428/ https://www.ncbi.nlm.nih.gov/pubmed/26120520 http://dx.doi.org/10.1007/s40629-014-0011-7 |
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