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Rupatadine: efficacy and safety of a non-sedating antihistamine with PAF-antagonist effects

Rupatadine is a modern non-sedating H1-antihistamine that also haswith additional antagonist effects on platelet-activating factor (PAF). Under the tradenames Rupafin® and Urtimed®, Rrupatadine is approvedregistered in Germany for the treatment of allergic rhinitis and urticaria infor adults and chi...

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Detalles Bibliográficos
Autores principales: Shamizadeh, Soja, Brockow, Knut, Ring, Johannes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Urban & Vogel 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479428/
https://www.ncbi.nlm.nih.gov/pubmed/26120520
http://dx.doi.org/10.1007/s40629-014-0011-7
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author Shamizadeh, Soja
Brockow, Knut
Ring, Johannes
author_facet Shamizadeh, Soja
Brockow, Knut
Ring, Johannes
author_sort Shamizadeh, Soja
collection PubMed
description Rupatadine is a modern non-sedating H1-antihistamine that also haswith additional antagonist effects on platelet-activating factor (PAF). Under the tradenames Rupafin® and Urtimed®, Rrupatadine is approvedregistered in Germany for the treatment of allergic rhinitis and urticaria infor adults and children aged over 12 years. In this review, the available literature available to date onregarding the pharmacological profile and clinical application of Rrupatadine is reviewed and compared to other conventional histamines. In conclusionFinally, the side effects, safety and interaction profileincompatibility of Rrupatadine are discussed. Due to CYP p450 metabolism, Rrupatadine should not be given together with Eerythromycin, Kketoconazole or grapefruit juice. Rupatadine has been found to be effective and safe Iin a variety of randomized clinical trials both in both seasonal and perennial allergic rhinitis, as well as inbut also chronic urticaria Rupatadine has been found as effective and safe.
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spelling pubmed-44794282015-06-26 Rupatadine: efficacy and safety of a non-sedating antihistamine with PAF-antagonist effects Shamizadeh, Soja Brockow, Knut Ring, Johannes Allergo J Int Review Article Rupatadine is a modern non-sedating H1-antihistamine that also haswith additional antagonist effects on platelet-activating factor (PAF). Under the tradenames Rupafin® and Urtimed®, Rrupatadine is approvedregistered in Germany for the treatment of allergic rhinitis and urticaria infor adults and children aged over 12 years. In this review, the available literature available to date onregarding the pharmacological profile and clinical application of Rrupatadine is reviewed and compared to other conventional histamines. In conclusionFinally, the side effects, safety and interaction profileincompatibility of Rrupatadine are discussed. Due to CYP p450 metabolism, Rrupatadine should not be given together with Eerythromycin, Kketoconazole or grapefruit juice. Rupatadine has been found to be effective and safe Iin a variety of randomized clinical trials both in both seasonal and perennial allergic rhinitis, as well as inbut also chronic urticaria Rupatadine has been found as effective and safe. Urban & Vogel 2014-05-09 2014 /pmc/articles/PMC4479428/ /pubmed/26120520 http://dx.doi.org/10.1007/s40629-014-0011-7 Text en © Urban & Vogel 2014
spellingShingle Review Article
Shamizadeh, Soja
Brockow, Knut
Ring, Johannes
Rupatadine: efficacy and safety of a non-sedating antihistamine with PAF-antagonist effects
title Rupatadine: efficacy and safety of a non-sedating antihistamine with PAF-antagonist effects
title_full Rupatadine: efficacy and safety of a non-sedating antihistamine with PAF-antagonist effects
title_fullStr Rupatadine: efficacy and safety of a non-sedating antihistamine with PAF-antagonist effects
title_full_unstemmed Rupatadine: efficacy and safety of a non-sedating antihistamine with PAF-antagonist effects
title_short Rupatadine: efficacy and safety of a non-sedating antihistamine with PAF-antagonist effects
title_sort rupatadine: efficacy and safety of a non-sedating antihistamine with paf-antagonist effects
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479428/
https://www.ncbi.nlm.nih.gov/pubmed/26120520
http://dx.doi.org/10.1007/s40629-014-0011-7
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