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Delivery of Topically Applied Calpain Inhibitory Peptide to the Posterior Segment of the Rat Eye

We developed an inhibitory peptide that specifically acts against mitochondrial μ-calpain (Tat-μCL, 23 amino acid, 2857.37 Da) and protects photoreceptors in retinal dystrophic rats. In the present study, we topically administered Tat-μCL to the eyes of Sprague-Dawley rats for 7 days to determine bo...

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Detalles Bibliográficos
Autores principales:	Ozaki, Taku, Nakazawa, Mitsuru, Yamashita, Tetsuro, Ishiguro, Sei-ichi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479448/ https://www.ncbi.nlm.nih.gov/pubmed/26107400 http://dx.doi.org/10.1371/journal.pone.0130986

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