Autoallergy in atopic dermatitis

The term autoallergy denotes autoimmunity accompanying an atopic disease, with antigen-specific IgE as a hallmark. This phenomenon is discussed to contribute to a chronification of the disease and to shape the immune response in chronic atopic dermatitis (AD). In this review, we highlight recent ins...

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Detalles Bibliográficos
Autores principales: Hradetzky, Susanne, Werfel, Thomas, Rösner, Lennart M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Urban & Vogel 2015
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479480/
https://www.ncbi.nlm.nih.gov/pubmed/26120543
http://dx.doi.org/10.1007/s40629-015-0037-5
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author Hradetzky, Susanne
Werfel, Thomas
Rösner, Lennart M.
author_facet Hradetzky, Susanne
Werfel, Thomas
Rösner, Lennart M.
author_sort Hradetzky, Susanne
collection PubMed
description The term autoallergy denotes autoimmunity accompanying an atopic disease, with antigen-specific IgE as a hallmark. This phenomenon is discussed to contribute to a chronification of the disease and to shape the immune response in chronic atopic dermatitis (AD). In this review, we highlight recent insights into the autoallergic inflammation in AD. Different mechanisms underlying the allergenicity of autoallergens are discussed at the moment: intrinsic functions modulating the immune system as well as molecular mimicry may influence the allergenic potential of these proteins. Finally, the role of specific T cells is discussed. Cite this as: Hradetzky S, Werfel T, Roesner LM. Autoallergy in atopic dermatitis. Allergo J Int 2015; 24:16–22 DOI: 10.1007/s40629-015-0037-5
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spelling pubmed-44794802015-06-26 Autoallergy in atopic dermatitis Hradetzky, Susanne Werfel, Thomas Rösner, Lennart M. Allergo J Int Review Article The term autoallergy denotes autoimmunity accompanying an atopic disease, with antigen-specific IgE as a hallmark. This phenomenon is discussed to contribute to a chronification of the disease and to shape the immune response in chronic atopic dermatitis (AD). In this review, we highlight recent insights into the autoallergic inflammation in AD. Different mechanisms underlying the allergenicity of autoallergens are discussed at the moment: intrinsic functions modulating the immune system as well as molecular mimicry may influence the allergenic potential of these proteins. Finally, the role of specific T cells is discussed. Cite this as: Hradetzky S, Werfel T, Roesner LM. Autoallergy in atopic dermatitis. Allergo J Int 2015; 24:16–22 DOI: 10.1007/s40629-015-0037-5 Urban & Vogel 2015-02-09 2015 /pmc/articles/PMC4479480/ /pubmed/26120543 http://dx.doi.org/10.1007/s40629-015-0037-5 Text en © Urban & Vogel 2015
spellingShingle Review Article
Hradetzky, Susanne
Werfel, Thomas
Rösner, Lennart M.
Autoallergy in atopic dermatitis
title Autoallergy in atopic dermatitis
title_full Autoallergy in atopic dermatitis
title_fullStr Autoallergy in atopic dermatitis
title_full_unstemmed Autoallergy in atopic dermatitis
title_short Autoallergy in atopic dermatitis
title_sort autoallergy in atopic dermatitis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479480/
https://www.ncbi.nlm.nih.gov/pubmed/26120543
http://dx.doi.org/10.1007/s40629-015-0037-5
work_keys_str_mv AT hradetzkysusanne autoallergyinatopicdermatitis
AT werfelthomas autoallergyinatopicdermatitis
AT rosnerlennartm autoallergyinatopicdermatitis

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