Preclinical Potency and Biodistribution Studies of an AAV 5 Vector Expressing Human Interferon-β (ART-I02) for Local Treatment of Patients with Rheumatoid Arthritis

INTRODUCTION: Proof of concept for local gene therapy for the treatment of arthritis with immunomodulatory cytokine interferon beta (IFN-β) has shown promising results in animal models of rheumatoid arthritis (RA). For the treatment of RA patients, we engineered a recombinant adeno-associated seroty...

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Detalles Bibliográficos
Autores principales: Aalbers, Caroline J., Bevaart, Lisette, Loiler, Scott, de Cortie, Karin, Wright, J. Fraser, Mingozzi, Federico, Tak, Paul P., Vervoordeldonk, Margriet J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479517/
https://www.ncbi.nlm.nih.gov/pubmed/26107769
http://dx.doi.org/10.1371/journal.pone.0130612

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479517/
https://www.ncbi.nlm.nih.gov/pubmed/26107769
http://dx.doi.org/10.1371/journal.pone.0130612

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