Cargando…

Alzheimer’s loci: epigenetic associations and interaction with genetic factors

OBJECTIVE: We explore the role of DNA methylation in Alzheimer’s disease (AD). To elucidate where DNA methylation falls along the causal pathway linking risk factors to disease, we examine causal models to assess its role in the pathology of AD. METHODS: DNA methylation profiles were generated in 74...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chibnik, Lori B, Yu, Lei, Eaton, Matthew L, Srivastava, Gyan, Schneider, Julie A, Kellis, Manolis, Bennett, David A, De Jager, Philip L
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Ltd 2015
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479524/ https://www.ncbi.nlm.nih.gov/pubmed/26125039 http://dx.doi.org/10.1002/acn3.201

Ejemplares similares

Reproductive period and epigenetic modifications of the oxidative phosphorylation pathway in the human prefrontal cortex
por: Bove, Riley M., et al.
Publicado: (2018)

Intermediate Phenotypes Identify Divergent Pathways to Alzheimer's Disease
por: Shulman, Joshua M., et al.
Publicado: (2010)

Trans-pQTL study identifies immune crosstalk between Parkinson and Alzheimer loci
por: Chan, Gail, et al.
Publicado: (2016)

24-Hour Rhythms of DNA Methylation and Their Relation with Rhythms of RNA Expression in the Human Dorsolateral Prefrontal Cortex
por: Lim, Andrew S. P., et al.
Publicado: (2014)

Retraction: 24-Hour Rhythms of DNA Methylation and Their Relation with Rhythms of RNA Expression in the Human Dorsolateral Prefrontal Cortex
por: Lim, Andrew S. P., et al.
Publicado: (2021)

Modulation of TREM2 by CD33: a protein QTL study integrates Alzheimer loci in human monocytes
por: Chan, Gail, et al.
Publicado: (2015)

Identification of genes associated with dissociation of cognitive performance and neuropathological burden: Multistep analysis of genetic, epigenetic, and transcriptional data
por: White, Charles C., et al.
Publicado: (2017)

Diurnal and seasonal molecular rhythms in human neocortex and their relation to Alzheimer's disease
por: Lim, Andrew S. P., et al.
Publicado: (2017)

Alzheimery's disease pathology is associated with early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci
por: De Jager, PL, et al.
Publicado: (2014)

UNC5C variants are associated with cerebral amyloid angiopathy
por: Yang, Hyun-Sik, et al.
Publicado: (2017)

Dissecting the role of non-coding RNAs in the accumulation of amyloid and tau neuropathologies in Alzheimer’s disease
por: Patrick, Ellis, et al.
Publicado: (2017)

Cell-type-specific Alzheimer’s disease polygenic risk scores are associated with distinct disease processes in Alzheimer’s disease
por: Yang, Hyun-Sik, et al.
Publicado: (2023)

Cell-type-specific Alzheimer’s disease polygenic risk scores are associated with distinct disease processes in Alzheimer’s disease
por: Yang, Hyun-Sik, et al.
Publicado: (2023)

Sex-Specific Association of the X Chromosome With Cognitive Change and Tau Pathology in Aging and Alzheimer Disease
por: Davis, Emily J., et al.
Publicado: (2021)

CD33 Alzheimer’s disease locus: Altered monocyte function and amyloid biology
por: Bradshaw, Elizabeth M, et al.
Publicado: (2013)

Regulatory genomic circuitry of human disease loci by integrative epigenomics
por: Boix, Carles A., et al.
Publicado: (2021)

The Molecular and Neuropathological Consequences of Genetic Risk for Alzheimer's Dementia
por: Tasaki, Shinya, et al.
Publicado: (2018)

Rate of brain aging and APOE ε4 are synergistic risk factors for Alzheimer’s disease
por: Glorioso, Christin A, et al.
Publicado: (2019)

Genetic insights into the association between inflammatory bowel disease and Alzheimer’s disease
por: Zeng, Lu, et al.
Publicado: (2023)

A molecular network of the aging human brain provides insights into the pathology and cognitive decline of Alzheimer’s disease
por: Mostafavi, Sara, et al.
Publicado: (2018)

Exome-wide age-of-onset analysis reveals exonic variants in ERN1 and SPPL2C associated with Alzheimer’s disease
por: He, Liang, et al.
Publicado: (2021)

The Role of MAPT Haplotype H2 and Isoform 1N/4R in Parkinsonism of Older Adults
por: Valenca, Guilherme T., et al.
Publicado: (2016)

Genome-wide epistasis analysis for Alzheimer’s disease and implications for genetic risk prediction
por: Wang, Hui, et al.
Publicado: (2021)

Complex relation of HLA-DRB1*1501, age at menarche, and age at multiple sclerosis onset
por: Bove, Riley, et al.
Publicado: (2016)

Genetic loci and metabolic states associated with murine epigenetic aging
por: Mozhui, Khyobeni, et al.
Publicado: (2022)

Interpreting non-coding variation in complex disease genetics
por: Ward, Lucas D., et al.
Publicado: (2012)

Sleep fragmentation, microglial aging, and cognitive impairment in adults with and without Alzheimer’s dementia
por: Kaneshwaran, Kirusanthy, et al.
Publicado: (2019)

Characteristics of Epigenetic Clocks Across Blood and Brain Tissue in Older Women and Men
por: Grodstein, Francine, et al.
Publicado: (2021)

Genome-wide interaction study of brain beta-amyloid burden and cognitive impairment in Alzheimer's disease
por: Roostaei, T, et al.
Publicado: (2017)

Elevated DNA methylation across a 48-kb region spanning the HOXA gene cluster is associated with Alzheimer’s disease neuropathology
por: Smith, Rebecca G., et al.
Publicado: (2018)

A Bayesian Framework for Generalized Linear Mixed Modeling Identifies New Candidate Loci for Late-Onset Alzheimer’s Disease
por: Wang, Xulong, et al.
Publicado: (2018)

Genetic and Epigenetic Fine Mapping of Complex Trait Associated Loci in the Human Liver
por: Çalışkan, Minal, et al.
Publicado: (2019)

Life Course Socioeconomic Status and Later Life Alzheimer’s Disease-Related Neuropathological Lesions
por: Tom, Sarah, et al.
Publicado: (2020)

Long-range epigenetic regulation is conferred by genetic variation located at thousands of independent loci
por: Lemire, Mathieu, et al.
Publicado: (2015)

Susceptibility to neurofibrillary tangles: role of the PTPRD locus and limited pleiotropy with other neuropathologies
por: Chibnik, Lori B, et al.
Publicado: (2017)

A Putative Alzheimer's Disease Risk Allele in PCK1 Influences Brain Atrophy in Multiple Sclerosis
por: Xia, Zongqi, et al.
Publicado: (2010)

HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants
por: Ward, Lucas D., et al.
Publicado: (2012)

Genetic architecture of age-related cognitive decline in African Americans
por: Raj, Towfique, et al.
Publicado: (2016)

Genetic risk for Alzheimer’s dementia predicts motor deficits through multi-omic systems in older adults
por: Tasaki, Shinya, et al.
Publicado: (2019)

The Epigenetics of Psychosis: A Structured Review with Representative Loci
por: Miller, Christine L.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_75sac39pmpmpt63lmesnabtud6