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Species-Specific Chromosome Engineering Greatly Improves Fully Human Polyclonal Antibody Production Profile in Cattle

Large-scale production of fully human IgG (hIgG) or human polyclonal antibodies (hpAbs) by transgenic animals could be useful for human therapy. However, production level of hpAbs in transgenic animals is generally very low, probably due to the fact that evolutionarily unique interspecies-incompatib...

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Detalles Bibliográficos
Autores principales:	Matsushita, Hiroaki, Sano, Akiko, Wu, Hua, Wang, Zhongde, Jiao, Jin-an, Kasinathan, Poothappillai, Sullivan, Eddie J., Kuroiwa, Yoshimi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479556/ https://www.ncbi.nlm.nih.gov/pubmed/26107496 http://dx.doi.org/10.1371/journal.pone.0130699

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