Cargando…

Species-Specific Chromosome Engineering Greatly Improves Fully Human Polyclonal Antibody Production Profile in Cattle

Large-scale production of fully human IgG (hIgG) or human polyclonal antibodies (hpAbs) by transgenic animals could be useful for human therapy. However, production level of hpAbs in transgenic animals is generally very low, probably due to the fact that evolutionarily unique interspecies-incompatib...

Descripción completa

Detalles Bibliográficos
Autores principales:	Matsushita, Hiroaki, Sano, Akiko, Wu, Hua, Wang, Zhongde, Jiao, Jin-an, Kasinathan, Poothappillai, Sullivan, Eddie J., Kuroiwa, Yoshimi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479556/ https://www.ncbi.nlm.nih.gov/pubmed/26107496 http://dx.doi.org/10.1371/journal.pone.0130699

Ejemplares similares

Triple Immunoglobulin Gene Knockout Transchromosomic Cattle: Bovine Lambda Cluster Deletion and Its Effect on Fully Human Polyclonal Antibody Production
por: Matsushita, Hiroaki, et al.
Publicado: (2014)

Physiological Level Production of Antigen-Specific Human Immunoglobulin in Cloned Transchromosomic Cattle
por: Sano, Akiko, et al.
Publicado: (2013)

Correction: Physiological Level Production of Antigen-Specific Human Immunoglobulin in Cloned Transchromosomic Cattle
por: Sano, Akiko, et al.
Publicado: (2014)

Production of Potent Fully Human Polyclonal Antibodies against Ebola Zaire Virus in Transchromosomal Cattle
por: Dye, John M., et al.
Publicado: (2016)

Acceleration of genetic gain in cattle by reduction of generation interval
por: Kasinathan, Poothappillai, et al.
Publicado: (2015)

Transcriptional reprogramming of gene expression in bovine somatic cell chromatin transfer embryos
por: Rodriguez-Osorio, Nelida, et al.
Publicado: (2009)

Assessment of genome integrity with array CGH in cattle transgenic cell lines produced by homologous recombination and somatic cell cloning
por: Liu, George E, et al.
Publicado: (2011)

Human Polyclonal Antibodies Produced from Transchromosomal Bovine Provides Prophylactic and Therapeutic Protections Against Zika Virus Infection in STAT2 KO Syrian Hamsters
por: Siddharthan, Venkatraman, et al.
Publicado: (2019)

Generation of H7N9-specific human polyclonal antibodies from a transchromosomic goat (caprine) system
por: Wu, Hua, et al.
Publicado: (2019)

Safety and tolerability of a novel, polyclonal human anti-MERS coronavirus antibody produced from transchromosomic cattle: a phase 1 randomised, double-blind, single-dose-escalation study
por: Beigel, John H, et al.
Publicado: (2018)

Correction: Triple Immunoglobulin Gene Knockout Transchromosomic Cattle: Bovine Lambda Cluster Deletion and Its Effect on Fully Human Polyclonal Antibody Production
Publicado: (2014)

Human Polyclonal Antibodies Produced through DNA Vaccination of Transchromosomal Cattle Provide Mice with Post-Exposure Protection against Lethal Zaire and Sudan Ebolaviruses
por: Bounds, Callie E., et al.
Publicado: (2015)

Transchromosomic bovine-derived anti-SARS-CoV-2 polyclonal human antibodies protects hACE2 transgenic hamsters against multiple variants
por: Gilliland, Theron, et al.
Publicado: (2023)

Impacts of polyclonal antibody preparations from avian origin on nutrient digestibility and performance of backgrounding beef cattle
por: Silva, Gleise M, et al.
Publicado: (2022)

Production of Erythropoietin-Specific Polyclonal Antibodies
por: Maboudi, Kourosh, et al.
Publicado: (2017)

Passive Monoclonal and Polyclonal Antibody Therapies
por: Pelletier, J. Peter R., et al.
Publicado: (2020)

Persistent polyclonal B‐cell lymphocytosis: Illustration of the great mimicker of low‐grade B‐cell lymphoma
por: Nkosi, Dingani, et al.
Publicado: (2022)

Back to the future: recombinant polyclonal antibody therapeutics
por: Wang, Xian-zhe, et al.
Publicado: (2013)

Monoclonal and Polyclonal Antibodies Specific to Human Fibromodulin
por: Farahi, Lia, et al.
Publicado: (2019)

Conjugation of R-Phycoerythrin to a Polyclonal Antibody and F (ab')2 Fragment of a Polyclonal Antibody by Two Different Methods
por: Mahmoudian, Jafar, et al.
Publicado: (2010)

Chromosomal Aberrations in Cattle
por: Holečková, Beáta, et al.
Publicado: (2021)

Single-Batch Production of Recombinant Human Polyclonal Antibodies
por: Nielsen, Lars S., et al.
Publicado: (2010)

Characterization of a novel polyclonal anti-hypusine antibody
por: Nishiki, Yurika, et al.
Publicado: (2013)

Polyclonal antibodies for the detection of Trypanosoma cruzi circulating antigens
por: Málaga-Machaca, Edith S., et al.
Publicado: (2017)

Development of Polyclonal Antibody against Clenbuterol for Immunoassay Application
por: Talib, Nurul Ain A., et al.
Publicado: (2018)

Antibodies in infectious diseases: polyclonals, monoclonals and niche biotechnology
por: Berry, Jody D., et al.
Publicado: (2011)

A tool for evaluating heterogeneity in avidity of polyclonal antibodies
por: Li, Kan, et al.
Publicado: (2023)

Uses and Challenges of Antiviral Polyclonal and Monoclonal Antibody Therapies
por: Struble, Evi B., et al.
Publicado: (2023)

Contact chains of cattle farms in Great Britain
por: Fielding, Helen R., et al.
Publicado: (2019)

Polyclonal antibody preparations from avian origin as a feed additive to beef cattle: ruminal fermentation during the step-up transition diets
por: Silva, Gleise M, et al.
Publicado: (2022)

Resistant prolactinoma: Is it monoclonal or polyclonal?
por: Kumar, K. V. S. Hari, et al.
Publicado: (2013)

Preparation and Characterization of a Polyclonal Antibody against Brominated Protein
por: Kambayashi, Yasuhiro, et al.
Publicado: (2009)

Non-specific polyclonal antibody response induced by Mycoplasma pneumoniae.
por: Biberfeld, G., et al.
Publicado: (1983)

Systematic profiling of polyclonal HIV antibodies and prediction of effector functions
por: Brown, E
Publicado: (2012)

Polyclonal Antibody Production for Membrane Proteins via Genetic Immunization
por: Hansen, Debra T., et al.
Publicado: (2016)

Production and application of polyclonal and monoclonal antibodies against Spiroplasma eriocheiris
por: Zhang, Ying, et al.
Publicado: (2015)

Requirement of a Blocking Step in Affinity Purification of Polyclonal Antibodies
por: Hamzehlou, Sepideh, et al.
Publicado: (2015)

Shaping Polyclonal Responses via Antigen-Mediated Antibody Interference
por: Yan, Le, et al.
Publicado: (2020)

Characterization of rabbit polyclonal antibody against camel recombinant nanobodies
por: Khalaf, Houssam-Eddin, et al.
Publicado: (2022)

A biophysical model of viral escape from polyclonal antibodies
por: Yu, Timothy C, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_d8ou0ta6r2sqgtm2rso40qnhvv