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Evidence for a Role of the Transcriptional Regulator Maid in Tumorigenesis and Aging
Maid is a helix-loop-helix protein that is involved in cell proliferation. In order to further elucidate its physiological functions, we studied Maid activity in two small fish model systems. We found that Maid expression was greatest in zebrafish liver and that it increased following partial hepate...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479567/ https://www.ncbi.nlm.nih.gov/pubmed/26107180 http://dx.doi.org/10.1371/journal.pone.0129950 |
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author | Fujisawa, Koichi Terai, Shuji Matsumoto, Toshihiko Takami, Taro Yamamoto, Naoki Nishina, Hiroshi Furutani-Seiki, Makoto Sakaida, Isao |
author_facet | Fujisawa, Koichi Terai, Shuji Matsumoto, Toshihiko Takami, Taro Yamamoto, Naoki Nishina, Hiroshi Furutani-Seiki, Makoto Sakaida, Isao |
author_sort | Fujisawa, Koichi |
collection | PubMed |
description | Maid is a helix-loop-helix protein that is involved in cell proliferation. In order to further elucidate its physiological functions, we studied Maid activity in two small fish model systems. We found that Maid expression was greatest in zebrafish liver and that it increased following partial hepatectomy. Maid levels were also high in hepatic preneoplastic foci induced by treatment of zebrafish with diethylnitrosamine (DEN), but low in hepatocellular carcinomas (HCC), mixed tumors, and cholangiocarcinomas developing in these animals. In DEN-treated transgenic medaka overexpressing Maid, hepatic BrdU uptake and proliferation were reduced. After successive breedings, Maid transgenic medaka exhibited decreased movement and a higher incidence of abnormal spine curvature, possibly due to the senescence of spinal cord cells. Taken together, our results suggest that Maid levels can influence the progression of liver cancer. In conclusion, we found that Maid is important regulator of hepatocarconogenesis and aging. |
format | Online Article Text |
id | pubmed-4479567 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-44795672015-06-29 Evidence for a Role of the Transcriptional Regulator Maid in Tumorigenesis and Aging Fujisawa, Koichi Terai, Shuji Matsumoto, Toshihiko Takami, Taro Yamamoto, Naoki Nishina, Hiroshi Furutani-Seiki, Makoto Sakaida, Isao PLoS One Research Article Maid is a helix-loop-helix protein that is involved in cell proliferation. In order to further elucidate its physiological functions, we studied Maid activity in two small fish model systems. We found that Maid expression was greatest in zebrafish liver and that it increased following partial hepatectomy. Maid levels were also high in hepatic preneoplastic foci induced by treatment of zebrafish with diethylnitrosamine (DEN), but low in hepatocellular carcinomas (HCC), mixed tumors, and cholangiocarcinomas developing in these animals. In DEN-treated transgenic medaka overexpressing Maid, hepatic BrdU uptake and proliferation were reduced. After successive breedings, Maid transgenic medaka exhibited decreased movement and a higher incidence of abnormal spine curvature, possibly due to the senescence of spinal cord cells. Taken together, our results suggest that Maid levels can influence the progression of liver cancer. In conclusion, we found that Maid is important regulator of hepatocarconogenesis and aging. Public Library of Science 2015-06-24 /pmc/articles/PMC4479567/ /pubmed/26107180 http://dx.doi.org/10.1371/journal.pone.0129950 Text en © 2015 Fujisawa et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Fujisawa, Koichi Terai, Shuji Matsumoto, Toshihiko Takami, Taro Yamamoto, Naoki Nishina, Hiroshi Furutani-Seiki, Makoto Sakaida, Isao Evidence for a Role of the Transcriptional Regulator Maid in Tumorigenesis and Aging |
title | Evidence for a Role of the Transcriptional Regulator Maid in Tumorigenesis and Aging |
title_full | Evidence for a Role of the Transcriptional Regulator Maid in Tumorigenesis and Aging |
title_fullStr | Evidence for a Role of the Transcriptional Regulator Maid in Tumorigenesis and Aging |
title_full_unstemmed | Evidence for a Role of the Transcriptional Regulator Maid in Tumorigenesis and Aging |
title_short | Evidence for a Role of the Transcriptional Regulator Maid in Tumorigenesis and Aging |
title_sort | evidence for a role of the transcriptional regulator maid in tumorigenesis and aging |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479567/ https://www.ncbi.nlm.nih.gov/pubmed/26107180 http://dx.doi.org/10.1371/journal.pone.0129950 |
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