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Proteasomal Degradation of Proinsulin Requires Derlin-2, HRD1 and p97

Patients with type 1 diabetes (T1D) suffer from beta-cell destruction by CD8(+) T-cells that have preproinsulin as an important target autoantigen. It is of great importance to understand the molecular mechanism underlying the processing of preproinsulin into these CD8(+) T-cell epitopes. We therefo...

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Detalles Bibliográficos
Autores principales:	Hoelen, Hanneke, Zaldumbide, Arnaud, van Leeuwen, Wouter F., Torfs, Ellen C. W., Engelse, Marten A., Hassan, Chopie, Lebbink, Robert Jan, de Koning, Eelco J., Resssing, Maaike E., de Ru, Arnoud H., van Veelen, Peter A., Hoeben, Rob C., Roep, Bart O., Wiertz, Emmanuel J. H. J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479611/ https://www.ncbi.nlm.nih.gov/pubmed/26107514 http://dx.doi.org/10.1371/journal.pone.0128206

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