Identification of a New Class of Antifungals Targeting the Synthesis of Fungal Sphingolipids

Recent estimates suggest that >300 million people are afflicted by serious fungal infections worldwide. Current antifungal drugs are static and toxic and/or have a narrow spectrum of activity. Thus, there is an urgent need for the development of new antifungal drugs. The fungal sphingolipid gluco...

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Detalles Bibliográficos
Autores principales: Mor, Visesato, Rella, Antonella, Farnoud, Amir M., Singh, Ashutosh, Munshi, Mansa, Bryan, Arielle, Naseem, Shamoon, Konopka, James B., Ojima, Iwao, Bullesbach, Erika, Ashbaugh, Alan, Linke, Michael J., Cushion, Melanie, Collins, Margaret, Ananthula, Hari Krishna, Sallans, Larry, Desai, Pankaj B., Wiederhold, Nathan P., Fothergill, Annette W., Kirkpatrick, William R., Patterson, Thomas, Wong, Lai Hong, Sinha, Sunita, Giaever, Guri, Nislow, Corey, Flaherty, Patrick, Pan, Xuewen, Cesar, Gabriele Vargas, de Melo Tavares, Patricia, Frases, Susana, Miranda, Kildare, Rodrigues, Marcio L., Luberto, Chiara, Nimrichter, Leonardo, Del Poeta, Maurizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Microbiology 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479701/
https://www.ncbi.nlm.nih.gov/pubmed/26106079
http://dx.doi.org/10.1128/mBio.00647-15

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