siRNA Screening Identifies the Host Hexokinase 2 (HK2) Gene as an Important Hypoxia-Inducible Transcription Factor 1 (HIF-1) Target Gene in Toxoplasma gondii-Infected Cells

Although it is established that oxygen availability regulates cellular metabolism and growth, little is known regarding how intracellular pathogens use host factors to grow at physiological oxygen levels. Therefore, large-scale human small interfering RNA screening was performed to identify host gen...

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Detalles Bibliográficos
Autores principales: Menendez, Matthew T., Teygong, Crystal, Wade, Kristin, Florimond, Celia, Blader, Ira J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Microbiology 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479703/
https://www.ncbi.nlm.nih.gov/pubmed/26106078
http://dx.doi.org/10.1128/mBio.00462-15

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479703/
https://www.ncbi.nlm.nih.gov/pubmed/26106078
http://dx.doi.org/10.1128/mBio.00462-15

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