Treating the Host Response to Ebola Virus Disease with Generic Statins and Angiotensin Receptor Blockers

Treatments targeting the Ebola virus may eventually be shown to work, but they will not have an impact on overall Ebola mortality in West Africa. Endothelial dysfunction is responsible for the fluid and electrolyte imbalances seen in Ebola patients. Because inexpensive generic statins and angiotensi...

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Detalles Bibliográficos
Autores principales: Fedson, David S., Jacobson, Jeffrey R., Rordam, Ole Martin, Opal, Steven M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Microbiology 2015
Materias:
Opinion/Hypothesis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479704/
https://www.ncbi.nlm.nih.gov/pubmed/26106080
http://dx.doi.org/10.1128/mBio.00716-15
Descripción
Sumario:Treatments targeting the Ebola virus may eventually be shown to work, but they will not have an impact on overall Ebola mortality in West Africa. Endothelial dysfunction is responsible for the fluid and electrolyte imbalances seen in Ebola patients. Because inexpensive generic statins and angiotensin receptor blockers restore endothelial barrier integrity, they can be used to treat the host response in these patients. In Sierra Leone, approximately 100 Ebola patients were treated with this combination, and reports indicate that survival was greatly improved.

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