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Blood Mercury and Insulin Resistance in Nondiabetic Koreans (KNHANES 2008-2010)

PURPOSE: Blood mercury levels are associated with inflammation, and chronic low-grade inflammation is a cause of insulin resistance. This study aimed to investigate the association between serum mercury and insulin resistance. MATERIALS AND METHODS: Subjects from the 2008-2010 Korean National Health...

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Autores principales: Kim, Kyu-Nam, Park, Soo-Jung, Choi, Beomhee, Joo, Nam-Seok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Yonsei University College of Medicine 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479861/
https://www.ncbi.nlm.nih.gov/pubmed/26069115
http://dx.doi.org/10.3349/ymj.2015.56.4.944
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author Kim, Kyu-Nam
Park, Soo-Jung
Choi, Beomhee
Joo, Nam-Seok
author_facet Kim, Kyu-Nam
Park, Soo-Jung
Choi, Beomhee
Joo, Nam-Seok
author_sort Kim, Kyu-Nam
collection PubMed
description PURPOSE: Blood mercury levels are associated with inflammation, and chronic low-grade inflammation is a cause of insulin resistance. This study aimed to investigate the association between serum mercury and insulin resistance. MATERIALS AND METHODS: Subjects from the 2008-2010 Korean National Health and Nutrition Examination Survey were selected (n=29235) and the relevant data of 5388 subjects (2643 males and 2745 females) were analyzed cross-sectionally. Homeostasis Model Assessment for Insulin Resistance (HOMA-IR) was compared according to blood mercury quartiles, and the odds ratio (OR) of having the highest quartile of HOMA-IR according to blood mercury quartiles was calculated. RESULTS: Blood mercury levels in men and women were 29.4 nmol/L and 20.5 nmol/L, respectively, and fasting blood sugar (FBS), insulin, and HOMA-IR were significantly correlated with blood mercury levels. The correlation was stronger in men than in women. In men, FBS and HOMA-IR showed step-wise increases as the quartiles of blood mercury increased; only HOMA-IR differed significantly in the third and fourth blood mercury quartiles, compared to the first quartile. In women, however, both FBS and HOMA-IR differed significantly in the third and fourth blood mercury quartiles, compared to the first quartile. Among men, the OR of being in the highest HOMA-IR quartile was greatest for the highest blood mercury quartile (OR=1.720, 95% CI; 1.172-2.526), compared with the lowest quartile. CONCLUSION: In this large population-based study, blood mercury levels were weakly correlated with HOMA-IR and may be a risk factor for insulin resistance in nondiabetic Koreans.
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spelling pubmed-44798612015-07-01 Blood Mercury and Insulin Resistance in Nondiabetic Koreans (KNHANES 2008-2010) Kim, Kyu-Nam Park, Soo-Jung Choi, Beomhee Joo, Nam-Seok Yonsei Med J Original Article PURPOSE: Blood mercury levels are associated with inflammation, and chronic low-grade inflammation is a cause of insulin resistance. This study aimed to investigate the association between serum mercury and insulin resistance. MATERIALS AND METHODS: Subjects from the 2008-2010 Korean National Health and Nutrition Examination Survey were selected (n=29235) and the relevant data of 5388 subjects (2643 males and 2745 females) were analyzed cross-sectionally. Homeostasis Model Assessment for Insulin Resistance (HOMA-IR) was compared according to blood mercury quartiles, and the odds ratio (OR) of having the highest quartile of HOMA-IR according to blood mercury quartiles was calculated. RESULTS: Blood mercury levels in men and women were 29.4 nmol/L and 20.5 nmol/L, respectively, and fasting blood sugar (FBS), insulin, and HOMA-IR were significantly correlated with blood mercury levels. The correlation was stronger in men than in women. In men, FBS and HOMA-IR showed step-wise increases as the quartiles of blood mercury increased; only HOMA-IR differed significantly in the third and fourth blood mercury quartiles, compared to the first quartile. In women, however, both FBS and HOMA-IR differed significantly in the third and fourth blood mercury quartiles, compared to the first quartile. Among men, the OR of being in the highest HOMA-IR quartile was greatest for the highest blood mercury quartile (OR=1.720, 95% CI; 1.172-2.526), compared with the lowest quartile. CONCLUSION: In this large population-based study, blood mercury levels were weakly correlated with HOMA-IR and may be a risk factor for insulin resistance in nondiabetic Koreans. Yonsei University College of Medicine 2015-07-01 2015-06-05 /pmc/articles/PMC4479861/ /pubmed/26069115 http://dx.doi.org/10.3349/ymj.2015.56.4.944 Text en © Copyright: Yonsei University College of Medicine 2015 http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kim, Kyu-Nam
Park, Soo-Jung
Choi, Beomhee
Joo, Nam-Seok
Blood Mercury and Insulin Resistance in Nondiabetic Koreans (KNHANES 2008-2010)
title Blood Mercury and Insulin Resistance in Nondiabetic Koreans (KNHANES 2008-2010)
title_full Blood Mercury and Insulin Resistance in Nondiabetic Koreans (KNHANES 2008-2010)
title_fullStr Blood Mercury and Insulin Resistance in Nondiabetic Koreans (KNHANES 2008-2010)
title_full_unstemmed Blood Mercury and Insulin Resistance in Nondiabetic Koreans (KNHANES 2008-2010)
title_short Blood Mercury and Insulin Resistance in Nondiabetic Koreans (KNHANES 2008-2010)
title_sort blood mercury and insulin resistance in nondiabetic koreans (knhanes 2008-2010)
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479861/
https://www.ncbi.nlm.nih.gov/pubmed/26069115
http://dx.doi.org/10.3349/ymj.2015.56.4.944
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